ArticleScience advances2025
Mobile human brain imaging using functional ultrasound.
Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Differential aperture modulation enables high-fidelity 3D photoacoustic imaging.Photoacoustics · 2026Article
- Simultaneous Functional Ultrasound, Intrinsic Optical Signal and Widefield Calcium Neuroimaging.bioRxiv : the preprint server for biology · 2026Article
- Microbubble Backscattering Intensity Improves the Sensitivity of Three-Dimensional (3-D) Functional Ultrasound Localization Microscopy (fULM).IEEE transactions on medical imaging · 2026Article
- Ultrasound-transparent neural interfaces for multimodal interaction.Npj flexible electronics · 2026Article
- Ultrasound Brain-Computer Interfaces for Transcranial Closed-Loop Neuromodulation.BME frontiers · 2026Article
- Microbubble Backscattering Intensity Improves the Sensitivity of Three-dimensional (3D) Functional Ultrasound Localization Microscopy (fULM).bioRxiv : the preprint server for biology · 2025Article
- Functional Ultrasound Imaging of Auditory Responses in Comatose Patients.Research (Washington, D.C.) · 2025Article
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Imagine being able to study the human brain in real-world scenarios while the subject displays natural behaviors such as locomotion, social interaction, or spatial navigation. The advent of ultrafast ultrasound imaging brings us closer to this goal with functional ultrasound imaging (fUSi), a mobile neuroimaging technique. Here, we present real-time fUSi monitoring of brain activity during walking in a subject with a clinically approved sonolucent skull implant. Our approach uses personalized 3D-printed fUSi helmets for stability, optical tracking for cross-modal validation with functional magnetic resonance imaging, advanced signal processing to estimate hemodynamic responses, and facial tracking of a lick licking paradigm. These combined efforts allowed us to show consistent fUSi signals over 20 months, even during high motion activities such as walking. These results demonstrate the feasibility of fUSi for monitoring brain activity in real-world contexts, marking an important milestone for fUSi-based insights in clinical and neuroscientific research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.