Evidence map›Paper›PMID 40532663›Full record

Trial reportCell reports. Medicine2025

Transcranial alternating current stimulation for treating spinocerebellar ataxia type 3: A randomized controlled trial.

Xinyuan Chen, Xia Liu, Wei Lin, Lin Zhang, Xiaoping Cheng, Ziqiang Huang, Wanli Zhang, Huating Zeng, Yanhua Lian, Yingjuan Zhang and 18 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cell reports. Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05557786 (The Treatment of Transcranial Alternating Current Stimulation（tACS）on Patients With Cerebellar Ataxia), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05557786 nacompletednot on this map

The Treatment of Transcranial Alternating Current Stimulation（tACS）on Patients With Cerebellar Ataxia: A Randomized, Triple-blind, Parallel-controlled Study

TypeinterventionalSponsorFirst Affiliated Hospital of Fujian Medical UniversityRan2022 to 2024Enrolled164ConditionsSpinocerebellar Ataxia Type 3, Multiple System Atrophy-cerebellar TypeArmsTranscranial Alternating Current Stimulation
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Xinyuan ChenDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China.
Xia LiuDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China; Department of Rehabilitation Medicine, Yantai Affiliated Hospital of Binzhou Medical University, Yantai 264100, China.
Wei LinDepartment of Neurology and Institute of Neurology of First Affiliated Hospital, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou 350005, China.
Lin ZhangDepartment of Radiology, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China.
Xiaoping ChengDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China.
Ziqiang HuangDepartment of Radiology, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China.
Wanli ZhangCollege of Mechanical Engineering and Automation, Fuzhou University, Fuzhou 350108, China.
Huating ZengDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China; Department of Rehabilitation Medicine, Jianou Municipal Hospital of Fujian Province, Jianou 353100, China.
Yanhua LianDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China.
Yingjuan ZhangDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China.
Mengcheng LiDepartment of Radiology, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China.
Naping ChenDepartment of Radiology, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China.
Shuna HuangDepartment of Clinical Research and Translation Center, The First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, China.
Zhaodi WangDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China.
Xichen WangDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China.
Zhenyi LiuDepartment of Radiology, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China.
Ruying YuanDepartment of Neurology and Institute of Neurology of First Affiliated Hospital, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou 350005, China.
Xuanyu ChenDepartment of Neurology and Institute of Neurology of First Affiliated Hospital, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou 350005, China.
Zhixian YeDepartment of Neurology and Institute of Neurology of First Affiliated Hospital, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou 350005, China.
Bi ChengDepartment of Neurology and Institute of Neurology of First Affiliated Hospital, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou 350005, China.
Yue ZhangCollege of Mechanical Engineering and Automation, Fuzhou University, Fuzhou 350108, China.
Qunlin ChenDepartment of Radiology, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China.
Duolao WangGlobal Health Trials Unit, Liverpool School of Tropical Medicine, Liverpool, UK.
Jun NiDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China. Electronic address: nijun1000@126.com.
Ning WangDepartment of Neurology and Institute of Neurology of First Affiliated Hospital, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou 350005, China; Department of Neurology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou 350212, China. Electronic address: ningwang@fjmu.edu.cn.
Ying FuDepartment of Neurology and Institute of Neurology of First Affiliated Hospital, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou 350005, China; Department of Neurology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou 350212, China; School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350005, China. Electronic address: fuying@fjmu.edu.cn.
Shirui GanDepartment of Neurology and Institute of Neurology of First Affiliated Hospital, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou 350005, China; Department of Neurology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou 350212, China. Electronic address: ganshirui@fjmu.edu.cn.
OSCCAR Investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There are no specific treatments for spinocerebellar ataxia type 3 (SCA3), a neurodegenerative disease causing cerebellar dysfunction. Transcranial alternating current stimulation (tACS) can improve cerebellar motor functions, and it has been shown to be safe and effective in treating neurological diseases. This randomized controlled trial (RCT) explored the effects of tACS on SCA3 patients. Participants received either 40-min, 70 Hz, 2 mA tACS or sham stimulation daily for 2 weeks. The primary outcome was met by 80% of the active-tACS group (32/40) and 10% of the sham group (4/40). The active group also showed significantly greater reductions in the Scale for Assessment and Rating of Ataxia (SARA) scores. No serious adverse events occurred, indicating high safety. Therefore, tACS is effective, safe, and feasible for treating SCA3. The study is registered at ClinicalTrials.gov (NCT05557786).

Indexed as

Machado-Joseph DiseaseTranscranial Direct Current StimulationAdultAgedFemaleHumansLongitudinal StudiesMaleMiddle AgedTreatment Outcomefunctional connectivitynon-invasive brain stimulationrandomized sham-controlled trialspinocerebellar ataxia type 3transcranial alternating current stimulation

Identifiers

PMID40532663
PMCPMC12208327

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.