Evidence map›Paper›PMID 40533220›Full record

ArticleBMJ open2025

Current status and prognostic factors of paediatric arterial ischaemic stroke in China: a study protocol for Chinese Paediatric Ischaemic Stroke Registry (CPISR).

Wanqiu Zhang, Bin Zhu, Gang Cai, Mingyang Niu, Cuirong Duan, Pan Zhang, Yingjie Xu, Lulu Xiao, Qiankun Li, Zhiwen Su and 4 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07550257 (Prospective Registry of Acute Ischemic Stroke in Children Under 18 Years Old in China), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07550257 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Prospective Registry of Acute Ischemic Stroke in Children Under 18 Years Old in China (KIDS-AIS-REGISTRY)

TypeobservationalSponsorGansu Provincial Maternal and Child Health Care HospitalRan2026 to 2029Enrolled1,000ConditionsAcute Ischemic Stroke (AIS), Pediatric StrokeArmsStandard Clinical Management
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Wanqiu ZhangDepartment of Neurology, The First Affiliated Hospital of USTC, Hefei, China.ORCID http://orcid.org/0009-0004-0639-1695
Bin ZhuDepartment of Pediatrics, The 7th Medical Center of Chinese PLA General Hospital, Beijing, China.
Gang CaiDepartment of Neurology, Affiliated Hospital of Guizhou Medical University, Guizhou Medical University, Guizhou, China.
Mingyang NiuDepartment of Critical Care Medicine, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Cuirong DuanDepartment of Nephrology and Rheumatology, Academy of Pediatrics of University of South China, Changsha, Hunan, China.
Pan ZhangDepartment of Neurology, The First Affiliated Hospital of USTC, Hefei, China.
Yingjie XuDepartment of Neurology, The First Affiliated Hospital of USTC, Hefei, China.
Lulu XiaoDepartment of Neurology, Nanjing Jinling Hospital, Nanjing, China.
Qiankun LiDepartment of Emergency, Panyu Maternal and Child Care Service Centre of Guangzhou Hexian Memorial Affiliated Hospital of Southern Medical University, Guangzhou, China.
Zhiwen SuDepartment of Neonatology, Guangzhou Medical University, Guangzhou, Guangdong, China.
Fan WuDepartment of Neonatology, Guangzhou Medical University, Guangzhou, Guangdong, China.
Wei LiDepartment of Neurology, The First Affiliated Hospital of Hainan Medical College, Haikou, Hainan, China.
Huiping WangDepartment of Neurology, Kunming Children's Hospital Affiliated with Kunming Medical University, Kunming, Yunan, China.
Wen SunDepartment of Neurology, The First Affiliated Hospital of USTC, Hefei, China sunwen_medneuro@163.com.ORCID http://orcid.org/0000-0002-7268-2085

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe treatment of paediatric AIS is particularly challenging due to its rarity, limited clinical awareness and absence of targeted treatment protocols and evidence-based data. This study aims to address these gaps by investigating the epidemiology, risk factors, aetiology and treatment of stroke in children in China and to observe the short-term and long-term functional outcomes of paediatric stroke and explore the factors that influence outcomes. METHOD AND ANALYSIS: The Chinese Paediatric Ischaemic Stroke Registry (CPISR) is a multicentre, prospective observational study that plans to consecutively recruit patients at 85 centres across 20 provinces in China. To streamline data collection, a WeChat-based programme has been developed to allow participating institutions to input standardised questionnaire data directly and upload electronic medical records. Comprehensive demographic, clinical, neuroimaging and laboratory data are collected and tracked for registered patients. All patients undergo detailed assessment at the time of admission and during scheduled follow-up visits. ETHICS AND DISSEMINATION: Ethical approval has been obtained from the Ethics Committee of the First Affiliated Hospital of University of Science and Technology of China (2022KY071). The findings of this study will be disseminated through peer-reviewed journals, national and international conference presentations and reports to participating institutions and relevant stakeholders. TRIAL REGISTRATION NUMBER: ChiCTR2200059915.

Indexed as

Ischemic StrokeAdolescentChildChild, PreschoolChinaEast Asian PeopleFemaleHumansInfantMaleMulticenter Studies as TopicObservational Studies as TopicPrognosisProspective StudiesRegistriesRisk FactorsAdolescentChildNEUROLOGYStroke

Identifiers

PMID40533220
PMCPMC12182019

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.