Evidence map›Paper›PMID 40533307›Full record

ArticleNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2025

Novel purine derivatives mitigate hypoxia ischemia related brain injury through agrin, zyxin and synaptotagmin proteins.

Aloïse Mabondzo, Clémence Disdier, Amal Bouzid, Khadidja Side Larbi, Amalia Tsintzou, Auriane Maïza, Boram Kim, Narciso Costa, Rania Harati, Anvi Laetitia Nguyen and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Aloïse MabondzoUniversité Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (MTS), SPI, Laboratoire d'Etude de l'Unité Neurovasculaire et Innovation Thérapeutique (LENIT), Gif-sur-Yvette Cedex 91191, France. Electronic address: aloise.mabondzo@cea.fr.
Clémence DisdierUniversité Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (MTS), SPI, Laboratoire d'Etude de l'Unité Neurovasculaire et Innovation Thérapeutique (LENIT), Gif-sur-Yvette Cedex 91191, France; Department of Pediatrics, Women & Infants Hospital of Rhode Island, Alpert Medical School of Brown University, Providence, 02905, United States.
Amal BouzidResearch Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.
Khadidja Side LarbiUniversité Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (MTS), SPI, Laboratoire d'Etude de l'Unité Neurovasculaire et Innovation Thérapeutique (LENIT), Gif-sur-Yvette Cedex 91191, France.
Amalia TsintzouUniversité Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (MTS), SPI, Laboratoire d'Etude de l'Unité Neurovasculaire et Innovation Thérapeutique (LENIT), Gif-sur-Yvette Cedex 91191, France.
Auriane MaïzaUniversité Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (MTS), SPI, Laboratoire d'Etude de l'Unité Neurovasculaire et Innovation Thérapeutique (LENIT), Gif-sur-Yvette Cedex 91191, France.
Boram KimDepartment of Pediatrics, Women & Infants Hospital of Rhode Island, Alpert Medical School of Brown University, Providence, 02905, United States.
Narciso CostaUniversité Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (MTS), SPI, Laboratoire d'Etude de l'Unité Neurovasculaire et Innovation Thérapeutique (LENIT), Gif-sur-Yvette Cedex 91191, France.
Rania HaratiResearch Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates; Department of Pharmacy Practice and Pharmacotherapeutics, College of Pharmacy, University of Sharjah, Sharjah, United Arab Emirates.
Anvi Laetitia NguyenUniversité Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (MTS), SPI, Laboratoire d'Etude de l'Unité Neurovasculaire et Innovation Thérapeutique (LENIT), Gif-sur-Yvette Cedex 91191, France.
Alain PruvostUniversité Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (MTS), SPI, Laboratoire d'Etude de l'Unité Neurovasculaire et Innovation Thérapeutique (LENIT), Gif-sur-Yvette Cedex 91191, France.
Hervé GalonsParis Cité University, Faculté des Sciences Pharmaceutiques et Biologiques, 4, Avenue de l'Observatoire, Paris Cedex 06, 75270, France.
Nassima OumataParis Cité University, Faculté des Sciences Pharmaceutiques et Biologiques, 4, Avenue de l'Observatoire, Paris Cedex 06, 75270, France.
Jean ArmengaudUniversité Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (DMTS), SPI, Bagnols-sur-Cèze, 30200, France.
Marlou KnijnenburgCentre of Perinatal Medicine and Health, Institute of Clinical Sciences, University of Gothenburg, Sweden.
Gaurav VermaCentre of Perinatal Medicine and Health, Institute of Clinical Sciences, University of Gothenburg, Sweden.
Henrik HagbergCentre of Perinatal Medicine and Health, Institute of Clinical Sciences, University of Gothenburg, Sweden.
Pierre GressensUniversité Paris Cité, NeuroDiderot, Inserm, F-75019 Paris, France.
Xiaodi F ChenDepartment of Pediatrics, Women & Infants Hospital of Rhode Island, Alpert Medical School of Brown University, Providence, 02905, United States.
Rifat A HamoudiResearch Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates; Centre of Excellence for Precision Medicine, Research Institute for Health and Medical Sciences, University of Sharjah, Sharjah, United Arab Emirates; BIMAI-Lab, Biomedically Informed Artificial Intelligence Laboratory, University of Sharjah, Sharjah, United Arab Emirates; Division of Surgery and Interventional Science, University College London, London, United Kingdom.
Barbara S StonestreetDepartment of Pediatrics, Women & Infants Hospital of Rhode Island, Alpert Medical School of Brown University, Providence, 02905, United States.

Funding

Neuroprotective Strategy: Novel Purine Derivatives for Neonatal Hypoxia-ischemiaR01NS117428 · NINDS · WOMEN AND INFANTS HOSPITAL-RHODE ISLAND · PI Xiaodi Felix Chen · 2021 to 2026
$2.4M
NINDS NIH HHS R01 NS117428
6 · The paper itself

Abstract

Hypoxic-ischemic encephalopathy (HIE) is a major cause of morbidity and mortality in newborns resulting in motor and cognitive impairment. Therapeutic hypothermia is the only treatment approved for HIE. Consequently, there is a critical requirement for additional treatments for hypoxic-ischemic (HI) brain injury because hypothermia is only partially protective. Pharmacological therapeutics are as yet not available to treat HIE. Therefore, we developed a novel trisubstituted purine-derivative drug (BRT_002) to attenuate HI related brain injury. The safety of BRT_002 was confirmed by treating adult rats with BRT_002 (100 ​mg/kg) for 7 days. Postnatal day-7 rats exposed to sham surgery or carotid ligation and 8% FiO

Indexed as

AgrinHypoxia-Ischemia, BrainNeuroprotective AgentsPurinesAnimalsAnimals, NewbornFemaleMaleMiceRatsRats, Sprague-DawleyAgrinNeuroprotective AgentsPurinesBlood-brain barrierBrain injuryHypoxia-ischemiaMitochondrial targetsNeuroprotectionPurine derivative drug candidate

Identifiers

PMID40533307
PMCPMC12491796

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.