Evidence map›Paper›PMID 40533324›Full record

ArticleTrends in genetics : TIG2025

Toward equitable biomarkers of aging: rethinking methylation clocks.

Selina Wu, Gita A Pathak, Zhangying Chen

Abstract readEditorial
In one paragraph

Article in Trends in genetics : TIG, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Association of Epigenetic Aging Biomarkers With Risk of MASLD-Related HCC.Liver international : official journal of the International Association for the Study of the Liver · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Selina WuDepartment of Medical Informatics, University of California Los Angeles, CA, USA.
Gita A PathakInstitute for Genomic Health, Icahn School of Medicine at Mount Sinai, NYC, NY, USA; Department of Genetics and Genomic sciences, Icahn School of Medicine at Mount Sinai, NYC, NY, USA.
Zhangying ChenDepartment of Neurology, Icahn School of Medicine at Mount Sinai, NYC, NY, USA. Electronic address: jennie.chen@mssm.edu.

Funding

Subject CollectionU10AA008401 · NIAAA · SUNY DOWNSTATE MEDICAL CENTER · PI JAY Arnold TISCHFIELD · 1989 to 2026
$162.7M
TUMOR CELL SURFACES AND CHROMOSOMEST32CA009056 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Gay M Crooks, David A. Nathanson · 1985 to 2026
$10.5M
Multi-modal intersection of depression and genetic liability to Alzheimers diseaseR00AG078503 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Gita A Pathak · 2024 to 2026
$741k
NCI NIH HHS T32 CA009056NIAAA NIH HHS U10 AA008401NIA NIH HHS R00 AG078503
6 · The paper itself

Abstract

DNA methylation clocks, which measure biological age by analyzing age-related DNA methylation patterns, offer powerful biomarkers of aging. But as a recent preprint highlights, current models underperform in diverse populations. The next generation of clocks must prioritize equity to avoid reinforcing disparities in precision aging and disease risk prediction.

Indexed as

AgingBiomarkersDNA MethylationEpigenesis, GeneticHumansBiomarkersagingmethylation clocksmulti-omics

Identifiers

PMID40533324
PMCPMC12221226

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.