Evidence map›Paper›PMID 40533521›Full record

ArticleNature cardiovascular research2025

Loss of effector T

Payel Roy, Anusha Bellapu, Sujit Silas Armstrong Suthahar, Mohammad Oliaeimotlagh, Qingkang Lyu, Smriti Parashar, Jeffrey Makings, Runpei Wu, Sunil Kumar, Megh Mehta and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature cardiovascular research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Oxidized LDL Induces Pro-Inflammatory Transcriptomic and Epigenomic Responses in Human CD4FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  3. Review
  4. Review
  5. ApoB-specific CD4Frontiers in immunology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Payel RoyDepartment of Physiology, Immunology Center of Georgia, Augusta University, Augusta, GA, USA. paroy@augusta.edu.ORCID http://orcid.org/0000-0003-2511-068X
Anusha BellapuDepartment of Physiology, Immunology Center of Georgia, Augusta University, Augusta, GA, USA.ORCID http://orcid.org/0000-0003-0605-1063
Sujit Silas Armstrong SuthaharLaboratory of Inflammation Biology, Center for Autoimmune Disease, La Jolla Institute for Immunology, La Jolla, CA, USA.
Mohammad OliaeimotlaghDepartment of Physiology, Immunology Center of Georgia, Augusta University, Augusta, GA, USA.
Qingkang LyuDepartment of Physiology, Immunology Center of Georgia, Augusta University, Augusta, GA, USA.
Smriti ParasharDepartment of Physiology, Immunology Center of Georgia, Augusta University, Augusta, GA, USA.ORCID http://orcid.org/0000-0002-6348-2612
Jeffrey MakingsLaboratory of Inflammation Biology, Center for Autoimmune Disease, La Jolla Institute for Immunology, La Jolla, CA, USA.
Runpei WuLaboratory of Inflammation Biology, Center for Autoimmune Disease, La Jolla Institute for Immunology, La Jolla, CA, USA.
Sunil KumarDepartment of Physiology, Immunology Center of Georgia, Augusta University, Augusta, GA, USA.
Megh MehtaDepartment of Physiology, Immunology Center of Georgia, Augusta University, Augusta, GA, USA.
Austin W T ChiangDepartment of Medicine, Immunology Center of Georgia, Augusta University, Augusta, GA, USA.
Alessandro SetteCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-7013-2250
Coleen A McNamaraCarter Immunology Center, University of Virginia, Charlottesville, VA, USA.ORCID http://orcid.org/0000-0002-0049-9986
Klaus LeyDepartment of Physiology, Immunology Center of Georgia, Augusta University, Augusta, GA, USA. kley@augusta.edu.ORCID http://orcid.org/0000-0001-9339-3672

Funding

Project 4: APOB-specific CD4 and CD8 T cells exacerbate atherosclerosisP01HL136275 · NHLBI · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI Catherine C Hedrick · 2017 to 2026
$25.5M
Vascular macrophages and T cells in atherosclerosisR35HL145241 · NHLBI · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI LEY, KLAUS F. · 2019 to 2025
$5.9M
NHLBI NIH HHS P01 HL136275NHLBI NIH HHS R35 HL145241U.S. Department of Health & Human Services | National Institutes of Health (NIH) HL136275U.S. Department of Health & Human Services | National Institutes of Health (NIH) HL145241
6 · The paper itself

Abstract

Atherosclerosis underlies most coronary artery disease (CAD). It involves a significant autoimmune component against apolipoprotein B (APOB). In this study, we used short activation-induced marker (AIM) assays to characterize APOB-reactive CD4

Indexed as

Coronary Artery DiseaseT-Lymphocytes, RegulatoryAgedAnimalsApolipoprotein B-100CD4-Positive T-LymphocytesFemaleGene Expression ProfilingHumansInterleukin-2 Receptor alpha SubunitMaleMiceMiddle AgedPlaque, AtheroscleroticSeverity of Illness IndexTranscriptomeAPOB protein, humanApolipoprotein B-100IL2RA protein, humanInterleukin-2 Receptor alpha Subunit

Identifiers

PMID40533521
PMCPMC13245147

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.