Evidence map›Paper›PMID 40533537›Full record

ArticleEMBO reports2025

Cotyledon opening during seedling deetiolation is determined by ABA-mediated splicing regulation.

Guiomar Martín, Ana Confraria, Irene Zapata, Alvaro Santiago Larran, Julia Irene Qüesta, Paula Duque

Abstract read
In one paragraph

Article in EMBO reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Guiomar MartínGIMM - Gulbenkian Institute for Molecular Medicine, Lisbon, Portugal. guiomar.martin@cragenomica.es.ORCID 0000-0001-6642-1666
Ana ConfrariaITQB NOVA - Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras, Portugal.ORCID 0000-0002-1685-9712
Irene ZapataCentre for Research in Agricultural Genomics, Cerdanyola del Vallés, Spain.
Alvaro Santiago LarranCentre for Research in Agricultural Genomics, Cerdanyola del Vallés, Spain.
Julia Irene QüestaCentre for Research in Agricultural Genomics, Cerdanyola del Vallés, Spain.ORCID 0000-0002-0462-8423
Paula DuqueGIMM - Gulbenkian Institute for Molecular Medicine, Lisbon, Portugal. paula.duque@gimm.pt.ORCID 0000-0002-4910-2900

Funding

EC | H2020 | PRIORITY 'Excellent science' | H2020 Marie Skłodowska-Curie Actions (MSCA) 945043EC | Horizon Europe | Excellent Science | HORIZON EUROPE Marie Sklodowska-Curie Actions (MSCA) 750469European Molecular Biology Organization (EMBO) ALTF 1576-2016MEC | Fundação para a Ciência e a Tecnologia (FCT) 2023.06360.CEECIND/CP2836/CT0009MEC | Fundação para a Ciência e a Tecnologia (FCT) CEECIND/02655/2017/CP1428/CT0003MEC | Fundação para a Ciência e a Tecnologia (FCT) PTDC/ASP-PLA/2550/2021,UIDB/ 04551/2020MEC | Fundação para a Ciência e a Tecnologia (FCT) PTDC/BIA-BID/30608/2017MEC | Fundação para a Ciência e a Tecnologia (FCT) UIDP/04551/2020Ministerio de Ciencia, Innovación y Universidades (MCIU) PID2021-125223NA-I00/MCIN/AEI/10.13039/501100011033/FEDERMinisterio de Ciencia, Innovación y Universidades (MCIU) RYC2021-032539-IRamόn y Cajal fellow RYC2020-030160_I; MCIN/AEI/10.13039/501100011033/FSE
6 · The paper itself

Abstract

During seedling deetiolation, plants adjust their development to expose photosynthetic tissues to sunlight, enabling the transition from heterotrophic to autotrophic growth. While various plant hormones are known to influence this process, the role of abscisic acid (ABA) remains unclear. Here, we reveal that ABA plays a major role in controlling the dynamics of cotyledon aperture during seedling deetiolation. In the dark, ABA accumulates in the cotyledons to effectively repress their opening. However, light exposure reverses this effect, allowing the cotyledons to open. Our findings indicate that ABA-mediated regulation of cotyledon dynamics is accompanied by genome-wide rearrangements in both transcriptional and splicing patterns. We demonstrate that ABA-dependent adjustments of cotyledon and splicing dynamics in response to light depend on the positive role of two splicing factors, RS40 and RS41. Moreover, we identify transcriptional and posttranscriptional mechanisms that control the activity of these proteins. Altogether, this work sheds light on the interplay between light and ABA, highlighting cotyledon opening as a new developmental outcome, and identifying alternative splicing as the underlying layer of gene regulation.

Indexed as

Abscisic AcidAlternative SplicingArabidopsisCotyledonEtiolationRNA SplicingSeedlingsArabidopsis ProteinsGene Expression Regulation, PlantLightRNA Splicing FactorsAbscisic AcidArabidopsis ProteinsRNA Splicing FactorsAbscisic AcidAlternative SplicingPhotomorphogenesisSeedling DeetiolationSR Proteins

Identifiers

PMID40533537
PMCPMC12287322

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.