ArticleNature2025
Single-cell transcriptomic and chromatin dynamics of the human brain in PTSD.
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Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33citing papers in PubMed
–field-weighted citation impact
What it found
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Who cites it
33 citing papers in PubMed.
- Posttraumatic stress disorder is associated with Alzheimer's disease-relevant molecular alterations in the basolateral amygdala of older Veterans.Neurobiology of aging · 2026Article
- Fast and slow gene expression changes in blood following acute social stress.Brain, behavior, & immunity - health · 2026Article
- Transcriptome changes of disinhibited somatostatin neurons in the medial prefrontal cortex mediating male-specific stress resilience.Research square · 2026Article
- Posttraumatic Stress Disorder Epigenome-Wide Association Studies in the Million Veteran Program.medRxiv : the preprint server for health sciences · 2026Article
- PKCα-deficient mice show altered synaptic signaling and impaired fear extinction.Neurobiology of stress · 2026Article
- Single-cell transcriptomics of human brain disorders.Molecular psychiatry · 2026Review
- Epigenomic priming of microglia bridges psychopathology and late-life cognitive decline.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Glial-neuronal crosstalk via GABA signaling: mechanistic insights into neuropsychiatric and neurological pathophysiology.Molecular psychiatry · 2026Review
- Dual proximity-based interactome mapping of FKBP51 and FKBP52 uncovers shared metabolic networks.Biochemical and biophysical research communications · 2026Article
- Mapping DNA Methylation Signatures to Identify Epigenetic Variation Across Subcortical Regions of the Human Posttraumatic Stress Disorder Brain.Biological psychiatry · 2026Article
- Postmortem brain single-nucleus and bulk gene expression analyses identify shared and distinct abnormalities in bipolar disorder and major depressive disorder.Translational psychiatry · 2026Article
- Variations of structural-functional coupling in post-traumatic stress disorder are associated with underlying molecular and transcriptional features.Psychological medicine · 2026Article
- A Comparison of Positive and Negative Allosteric Modulators of α5-Containing GABABiological psychiatry · 2026Review
- Alterations of microRNAs across human and mouse limbic brain areas: molecular mechanisms and biological processes involved in major depressive disorder.Neurobiology of stress · 2026Article
- Disorganized attachment and identity dissociation: FKBP5 CATT as a molecular moderator.Psychiatry research · 2026Article
- Inflammatory markers in the emergency department and PTSD symptoms in the AURORA Study: A longitudinal cohort study.Psychological medicine · 2026Article
- Inhibition of FKBP51 alleviates depressive-like behaviors via AKT/mTOR-dependent autophagy and synaptic plasticity.The international journal of neuropsychopharmacology · 2026Article
- Transcriptomic insights into the co-occurring psychological symptoms and cardiovascular risks among military service members and veterans with mild traumatic brain injury: A LIMBIC-CENC study.Brain, behavior, & immunity - health · 2026Article
- From classic circuits to novel mechanisms: How lncRNA, neuroinflammation, and iPSC models address the translational crisis in PTSD research.Comprehensive psychoneuroendocrinology · 2026Review
- Multi-ancestry genome-wide association and integrated multi-omics analyses of endometriosis and its clinical manifestations.Nature genetics · 2026Article
Corrections and comments
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Authors and funding
38 authors.
Ahyeon Hwang *Mathematical, Computational and Systems Biology Program, University of California Irvine, Irvine, CA, USA.
Mario Skarica *Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-2478-014X
Siwei Xu *Department of Computer Science, University of California Irvine, Irvine, CA, USA.ORCID 0000-0002-2828-3706
Jensine CoudrietDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Che Yu LeeDepartment of Computer Science, University of California Irvine, Irvine, CA, USA.ORCID 0000-0002-3039-4894
Lin LinDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-9640-0687
Rosemarie TerwilligerDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Alexa-Nicole SlibyDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Jiawei WangDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0003-2627-4897
Tuan NguyenDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-1703-0404
Hongyu LiDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0001-6525-9310
Min WuDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Yi DaiDepartment of Computer Science, University of California Irvine, Irvine, CA, USA.ORCID 0009-0004-1018-5931
Ziheng DuanDepartment of Computer Science, University of California Irvine, Irvine, CA, USA.ORCID 0000-0003-4696-0042
Shushrruth Sai SrinivasanMathematical, Computational and Systems Biology Program, University of California Irvine, Irvine, CA, USA.
Xiangyu ZhangDepartment of Biostatistics, Yale University School of Public Health, New Haven, CT, USA.
Yingxin LinDepartment of Biostatistics, Yale University School of Public Health, New Haven, CT, USA.ORCID 0000-0002-4299-7326
Dianne CruzDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA.
P J Michael DeansDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Traumatic Stress Brain Research Group
Bertrand R HuberNational Center for PTSD, US Department of Veterans Affairs, White River Junction, VT, USA.
Daniel LeveyDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0001-8431-9569
Jill R GlausierDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID 0000-0001-9838-3414
David A LewisDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID 0000-0002-3225-6778
Joel GelernterDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-4067-1859
Paul E HoltzheimerNational Center for PTSD, US Department of Veterans Affairs, White River Junction, VT, USA.
Matthew J FriedmanNational Center for PTSD, US Department of Veterans Affairs, White River Junction, VT, USA.ORCID 0000-0002-0497-6890
Mark GersteinDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA.
Nenad SestanDepartment of Neuroscience, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0003-0966-9619
Kristen J BrennandDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0003-0993-5956
Ke XuDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-6472-7052
Hongyu ZhaoDepartment of Biostatistics, Yale University School of Public Health, New Haven, CT, USA.ORCID 0000-0003-1195-9607
John H KrystalDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0001-6952-1726
Keith A YoungCentral Texas Veterans Health Care System, Research Service, Temple, TX, USA.ORCID 0000-0001-6060-3573
Douglas E WilliamsonDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA.
Alicia CheDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-7530-8531
Jing ZhangMathematical, Computational and Systems Biology Program, University of California Irvine, Irvine, CA, USA. zhang.jing@uci.edu.ORCID 0000-0002-5970-0509
Matthew J GirgentiDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA. matthew.girgenti@yale.edu.ORCID 0000-0003-1647-326X
Funding
Interpretable Deep Learning Methods to Investigate Genetics and Epigenetics of Alzheimer's Disease at a Single-Cell ResolutionR01NS128523 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI JING ZHANG · 2022 to 2026
$3.2MDecoding the Noncoding Regulatory Genome with Super-resolution via Single-cell Multiomics IntegrationR01HG012572 · NHGRI · UNIVERSITY OF CALIFORNIA-IRVINE · PI JING ZHANG · 2022 to 2026
$2.0MMolecular Dissection of Alcohol Use Disorder Through Targeted Brain Multi-omicsR01AA031017 · NIAAA · YALE UNIVERSITY · PI Matthew J Girgenti · 2024 to 2026
$1.7MNeural Mechanisms Linking Sensory Perception and Social BehaviorR01NS133434 · NINDS · YALE UNIVERSITY · PI Alicia Yue Che · 2023 to 2026
$1.6MEffects of Early-life Cannabinoid Exposure on Prefrontal Circuitry and Cognitive Behavior across DevelopmentR01DA059378 · NIDA · YALE UNIVERSITY · PI Alicia Yue Che · 2024 to 2026
$1.5MFunctional convergence following disruption of diverse genes associated with cannabis use and major depressionDP1DA060811 · NIDA · YALE UNIVERSITY · PI Matthew J Girgenti · 2024 to 2026
$1.3MNHGRI NIH HHS R01 HG012572NIAAA NIH HHS R01 AA031017NIDA NIH HHS DP1 DA060811NIDA NIH HHS R01 DA059378NINDS NIH HHS R01 NS128523NINDS NIH HHS R01 NS133434
Abstract
Post-traumatic stress disorder (PTSD) is a polygenic disorder occurring after extreme trauma exposure. Recent studies have begun to detail the molecular biology of PTSD. However, given the array of PTSD-perturbed molecular pathways identified so far
Indexed as
BrainChromatinSingle-Cell AnalysisStress Disorders, Post-TraumaticTranscriptomeEndothelial CellsEpigenesis, GeneticEpigenomeFemaleHumansMajor Depressive DisorderMaleMicrogliaMiddle AgedNeuronsPrefrontal CortexChromatinTacrolimus Binding Protein 5Tacrolimus Binding Proteins
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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.