Evidence map›Paper›PMID 40533613›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2025

Role of hematological parameters and inflammatory indices in determining the severity of obstructive sleep apnea syndrome: reality or myth?

Ayşe Seçil Kayali Dinç, Nagihan Gülhan Yaşar, Agah Yeniçeri, İrem Ağgünlü, Nurcan Yurtsever Kum, Melih Çayönü

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In one paragraph

Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Reconsidering the null finding: the critical impact of control group selection and confounder adjustment in assessing OSAS severity with inflammatory indices.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Ayşe Seçil Kayali DinçAnkara Bilkent City Hospital, Department of Otorhinolaryngology, Head and Neck Surgery, Ankara Bilkent Şehir Hastanesi, Genel Hastane, KBB Kliniği, Üniversiteler, 1604. Cd. No: 9, 06800, Bilkent, Ankara, Turkey. secilkayali81@yahoo.com.ORCID http://orcid.org/0000-0001-9004-8806
Nagihan Gülhan YaşarAnkara Bilkent City Hospital, Department of Otorhinolaryngology, Head and Neck Surgery, Ankara Bilkent Şehir Hastanesi, Genel Hastane, KBB Kliniği, Üniversiteler, 1604. Cd. No: 9, 06800, Bilkent, Ankara, Turkey.
Agah YeniçeriAnkara Bilkent City Hospital, Department of Otorhinolaryngology, Head and Neck Surgery, Ankara Bilkent Şehir Hastanesi, Genel Hastane, KBB Kliniği, Üniversiteler, 1604. Cd. No: 9, 06800, Bilkent, Ankara, Turkey.
İrem AğgünlüAnkara Bilkent City Hospital, Department of Otorhinolaryngology, Head and Neck Surgery, Ankara Bilkent Şehir Hastanesi, Genel Hastane, KBB Kliniği, Üniversiteler, 1604. Cd. No: 9, 06800, Bilkent, Ankara, Turkey.
Nurcan Yurtsever KumAnkara Bilkent City Hospital, Department of Otorhinolaryngology, Head and Neck Surgery, Ankara Bilkent Şehir Hastanesi, Genel Hastane, KBB Kliniği, Üniversiteler, 1604. Cd. No: 9, 06800, Bilkent, Ankara, Turkey.
Melih ÇayönüAnkara Bilkent City Hospital, Department of Otorhinolaryngology, Head and Neck Surgery, Ankara Bilkent Şehir Hastanesi, Genel Hastane, KBB Kliniği, Üniversiteler, 1604. Cd. No: 9, 06800, Bilkent, Ankara, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeObstructive sleep apnea syndrome (OSAS) affects a substantial portion of the adult population, and chronic inflammation plays a crucial role in its pathophysiology. This study aimed to investigate the effectiveness of blood parameters and inflammatory indices in predicting OSAS severity.

methodsPatients diagnosed with OSAS who presented to our clinic between December 2009 and December 2024 were included in the study. OSAS severity was determined based on polysomnography results. Blood parameters obtained during hospitalization were recorded. The following hematological indices were calculated from blood parameters: neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), prognostic nutritional index(PNI), pan-immune-inflammation value (PIV), and hemoglobin, albumin, lymphocyte, and platelet (HALP) index. Moreover, the potential role of these hematological parameters and indices in determining OSAS severity was investigated.

resultsA total of 1009 patients were included in the study. Among them, 106 had simple snoring, 214 had mild OSAS, 224 had moderate OSAS, and 465 had severe OSAS. No significant association was observed between OSAS severity and blood parameters, including albumin level, hemoglobin level, leukocyte count, neutrophil count, lymphocyte count, and platelet count, delta neutrophil index (DNI) (p-values: 0.083, 0.483, 0.347, 0.555, 0.878, 0.220, 0.459, respectively). Additionally, no significant correlation was observed between OSAS severity and hematological inflammatory indices such as NLR, PLR, SII, PNI, PIV, and HALP Index (p-values: 0.919, 0.369, 0.701, 0.581, 0.397, 0.503, respectively).

conclusionInflammatory processes play a role in the pathophysiology of OSAS; however, the present study revealed no relationship between OSAS severity and hematological inflammatory indices.

Indexed as

InflammationSleep Apnea, ObstructiveAdultAgedFemaleHemoglobinsHumansMaleMiddle AgedNeutrophilsPolysomnographyRetrospective StudiesSeverity of Illness IndexHemoglobinsInflammatory markersOSASPolysomnographySeverity

Identifiers

PMID40533613

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.