Evidence map›Paper›PMID 40533695›Full record

Trial reportOdontology2026

The impact of using cold irrigation on postoperative endodontic pain and substance P level: a randomized clinical trial.

Reem Mohammed Amr Sharaf, Tariq Yehia Abdelrahman, Maram Farouk Obeid

3 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Odontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06106386 nacompletednot on this map

The Impact of Using Cold Irrigation on Postoperative Endodontic Pain and Substance P Level: a Randomized Clinical Trial

TypeinterventionalSponsorAin Shams UniversityRan2024 to 2024Enrolled135ConditionsPost Operative Pain, InflammationArmscryotherapy
NCT07138365 nacompletednot on this map

Clinical and Biochemical Effects Of Different Cryotherapy Protocols On Endodontic Treated Mandibular Premolars With Symptomatic Apical Periodontitis: A Randomized Clinical Trial

TypeinterventionalSponsorAin Shams UniversityRan2024 to 2025Enrolled180ConditionsPost Operative Pain, InflammationArmsoral Cryotherapy, Intra radicular Cryotherapy, cold irrigation
NCT07676409 nanot yet recruitingnot on this map

Effect of Two Intracanal Cryotherapy Irrigation Protocols on Postoperative Endodontic Pain in Patients With Symptomatic Irreversible Pulpitis and Apical Periodontitis in Mandibular Molars: A Randomized Clinical Trial.

TypeinterventionalSponsorCairo UniversityRan2026 to 2027Enrolled45ConditionsCryotherapyArmsFull Cryotherapy Irrigation (FC), Final Flush Cryotherapy Irrigation (FFC), Conventional Irrigation (CI)
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Reem Mohammed Amr SharafDepartment of Endodontics, Faculty of Dentistry, Ain Shams University, Cairo, Egypt.ORCID http://orcid.org/0009-0008-2590-8409
Tariq Yehia AbdelrahmanDepartment of Endodontics, Faculty of Dentistry, Ain Shams University, Cairo, Egypt.ORCID http://orcid.org/0000-0002-8574-285X
Maram Farouk ObeidDepartment of Endodontics, Faculty of Dentistry, Ain Shams University, Cairo, Egypt. Maramobeid@dent.asu.edu.eg.ORCID http://orcid.org/0000-0001-7275-6833

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Various strategies have been employed to alleviate postoperative-endodontic pain (POP), with cryotherapy emerging as a promising approach. This randomized clinical trial aimed to evaluate the effectiveness of cold sodium hypochlorite (NaOCl) irrigation at 2.5 °C throughout chemo-mechanical preparation in reducing POP intensity and substance P (SP) levels in patients with irreversible pulpitis and symptomatic apical periodontitis. Following administration of anesthesia and determining the working length, the first apical fluid sample was collected. The biomechanical preparation was carried out based on the group allocation. The Cold/Irr group received irrigation with cold 2.5% NaOCl at 2.5 °C throughout the procedure and a final rinse with cold 2.5 °C saline for 10 min. The Cryo group received irrigation with 2.5% NaOCl at room temperature and a final rinse with cold 2.5 °C saline for 10 min. The control group received irrigation with 2.5% NaOCl at room temperature and final rinse with room temperature saline. Second sample of apical fluid was obtained prior to the obturation. Patients filled out a Visual Analog Scale (VAS) questionnaire to evaluate POP. The levels of SP were determined using the enzyme-linked immunosorbent assay (ELISA). The VAS scores in the control group were significantly higher than those in the other groups (p < 0.001). Also, the control group exhibited significantly higher analgesics intake compared to other groups (p = 0.001). The Cold/Irr group demonstrated a significant decrease in the percentage of SP (p < 0.001). A strong positive correlation was observed between SP and pain levels before and 6 h after treatment. Cryotherapy techniques offer a straightforward approach to reducing POP and SP and alleviating the need for analgesics in patients with symptomatic apical periodontitis. The trial registration number at ClinicalTrials.gov is NCT06106386 with initial release date 24/10/2023.

Indexed as

CryotherapyPeriapical PeriodontitisPostoperative PainPulpitisRoot Canal IrrigantsSodium HypochloriteSubstance PTherapeutic IrrigationAdultCold TemperatureFemaleHumansMaleMiddle AgedPain MeasurementRoot Canal PreparationRoot Canal IrrigantsSodium HypochloriteSubstance PCold irrigationCryotherapyPostoperative painSubstance P

Identifiers

PMID40533695
PMCPMC13053557

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.