Evidence map›Paper›PMID 40533707›Full record

ArticleInternational journal of behavioral medicine2026

Impact of Social Isolation on Inflammatory Bowel Disease Risk and the Mitigating Effect of a Healthy Lifestyle.

Liang Chang, Jie Zhang, Mengmeng Xu, Miaomiao Zhang, Wenhui Xu, Shuangye Yu, Dongqing Ye, Xinyu Fang

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Article in International journal of behavioral medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Liang ChangDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, hefei, China.
Jie ZhangAnhui University of Science and Technology, Huainan, China.
Mengmeng XuDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, hefei, China.
Miaomiao ZhangDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, hefei, China.
Wenhui XuDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, hefei, China.
Shuangye YuDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, hefei, China.
Dongqing YeDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, hefei, China.
Xinyu FangDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, hefei, China. xinyufang@ahmu.edu.cn.

Funding

Anhui Province clinical medical research transformation project NO. 202304295107020048; NO.20230429510702004the Research Innovation Team Project of the School of Public Health, Anhui Medical University kctd200403
6 · The paper itself

Abstract

backgroundWe aimed to evaluate the association of social isolation with incident inflammatory bowel disease (IBD) risk, as well as to investigate whether and to what degree a healthy lifestyle attenuates IBD risk linked to social isolation.

methodsThis UK Biobank cohort study included 429,843 participants without a prior diagnosis of IBD. Social isolation was assessed by three dimensions: the frequency of contact with family or friends, the frequency of engagement in leisure or social activities, and the number of family members. A healthy lifestyle considered included five factors: never smoking, a healthy diet, regular physical activity, an adequate body mass index, and sleep duration. We used multivariable Cox proportional hazards regression models to test the association. Stratified and joint analyses were used to further examine the role of a healthy lifestyle.

resultsDuring a median follow-up period of 13.3 years, 2762 IBD cases were identified, including 956 Crohn's disease (CD) and 1806 ulcerative colitis (UC) cases. Social isolation (most isolated vs least isolated) was associated with an increased risk of IBD (hazard ratio (HR) = 1.28, 95%CI 1.13-1.45), UC (HR = 1.23, 95%CI 1.05-1.43), and CD (HR = 1.34, 95%CI 1.08-1.66). Among the most isolated participants, adhering to a favorable lifestyle decreased the risk of IBD (HR = 0.53, 95%CI 0.36-0.78) and CD (HR = 0.31, 95%CI 0.14-0.69), but not UC.

conclusionsSocial isolation is associated with a higher risk of IBD and its subtypes. However, adhering to a healthy lifestyle substantially attenuates IBD and CD risks linked to social isolation.

Indexed as

Colitis, UlcerativeCrohn DiseaseHealthy LifestyleInflammatory Bowel DiseasesSocial IsolationAdultAgedCohort StudiesFemaleHumansMaleMiddle AgedRisk FactorsUnited KingdomHealthy lifestylesInflammatory bowel diseaseProspective cohort studyRiskSocial isolation

Identifiers

PMID40533707

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.