Evidence map›Paper›PMID 40533708›Full record

ReviewMolecular biology reports2025

Circular RNA rising star: new findings of circPRMT5 in cancer.

DuanZhong Chen, CaiYan Yin, Chao Li, Jun He, Peng Wu

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

DuanZhong ChenDepartment of Clinical Laboratory, Hengyang Medical School, The Affiliated Nanhua Hospital, University of South China, Hengyang, 421001, Hunan, China.
CaiYan YinDepartment of Clinical Laboratory, Hengyang Medical School, The Affiliated Nanhua Hospital, University of South China, Hengyang, 421001, Hunan, China.
Chao LiDepartment of Clinical Laboratory, Hengyang Medical School, The Affiliated Nanhua Hospital, University of South China, Hengyang, 421001, Hunan, China.
Jun HeDepartment of Clinical Laboratory, Hengyang Medical School, The Affiliated Nanhua Hospital, University of South China, Hengyang, 421001, Hunan, China. junhe2008@163.com.
Peng WuDepartment of Clinical Laboratory, Hengyang Medical School, The Affiliated Nanhua Hospital, University of South China, Hengyang, 421001, Hunan, China. PengWuNanhuaun@163.com.

Funding

Guiding project of Hengyang Science and Technology Bureau 2021181Hunan Provincial Health Commission Project C202302056128Hunan Provincial Health Committee 20201915Natural Science Foundation of Hunan province 2022JJ40016the Hengyang Science and Technology Planning Project 202250045307the Scientific Research Project of the National Natural Science Foundation of China 82000421
6 · The paper itself

Abstract

Circular RNA (circRNA), a type of noncoding RNA, features a covalently closed circular structure lacking 5'-3' polarity and a polyadenylated tail. Its resistance to RNase R degradation endows it with greater stability and resilience than linear RNA, leading to a prolonged half-life. Recent research has highlighted the crucial role of circRNAs, especially circPRMT5, in diverse cancers. CircPRMT5 is generated by reverse splicing of exon 18 within a 682-nucleotide gene. In various cancer cells, elevated circPRMT5 expression is correlated with increased tumor cell proliferation, migration, and invasion abilities. It impacts tumor progression by regulating cell proliferation, migration, invasion, and chemotherapy resistance. This review comprehensively examines the expression patterns, mechanisms, and clinical potential of circPRMT5 in cancers such as breast, bladder, nonsmall cell lung, esophageal, thyroid, liver, colorectal, and gastric cancer. Overall, circPRMT5 shows promise as a biomarker and therapeutic target, providing valuable insights for future cancer research and treatment strategies.

Indexed as

NeoplasmsProtein-Arginine N-MethyltransferasesRNA, CircularBiomarkers, TumorCell MovementCell ProliferationGene Expression Regulation, NeoplasticHumansBiomarkers, TumorPRMT5 protein, humanProtein-Arginine N-MethyltransferasesRNA, CircularCancerCircPRMT5Circular RNADrug resistanceMechanismsTherapy

Identifiers

PMID40533708

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.