Evidence map›Paper›PMID 40533714›Full record

ArticleAging clinical and experimental research2025

Polypharmacy and sarcopenia in patients on hemodialysis: results from the SARC-HD study.

Marvery P Duarte, Nicolle P Marinheiro, Odimar Q Junior, Otávio T Nóbrega, Jéssica G Roure, Fábio A Vieira, Jacqueline F Santana, Maryanne Z C Silva, Dario R Mondini, Henrique S Disessa and 10 more

Abstract read
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In one paragraph

Article in Aging clinical and experimental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Marvery P Duarte *Faculty of Health Sciences, University of Brasilia, Brasília, Brazil.ORCID http://orcid.org/0000-0002-4467-7713
Nicolle P Marinheiro *University Center ICESP, Brasília, Brazil.ORCID http://orcid.org/0000-0003-0841-9423
Odimar Q JuniorUniversity Center ICESP, Brasília, Brazil.ORCID http://orcid.org/0009-0001-8903-2767
Otávio T NóbregaFaculty of Health Sciences, University of Brasilia, Brasília, Brazil.ORCID http://orcid.org/0000-0003-1775-7176
Jéssica G RoureFaculty of Medicine, University of Brasilia, Brasília, Brazil.ORCID http://orcid.org/0000-0002-4185-8076
Fábio A VieiraFaculty of Health Sciences, University of Brasilia, Brasília, Brazil.ORCID http://orcid.org/0009-0004-4592-3498
Jacqueline F SantanaHospital de Base do Distrito Federal, Brasília, Brazil.ORCID http://orcid.org/0009-0004-2918-3012
Maryanne Z C SilvaInternal Medicine Department, Botucatu Medical School, Sao Paulo State University, UNESP, Botucatu, Brazil.ORCID http://orcid.org/0000-0001-6602-3625
Dario R MondiniApplied Kinesiology Laboratory, School of Physical Education, Universidade Estadual de Campinas, Campinas, Brazil.ORCID http://orcid.org/0000-0003-3605-0571
Henrique S DisessaDepartment of Physical Education, School of Sciences, Sao Paulo State University, UNESP, Bauru, Brazil.ORCID http://orcid.org/0000-0002-3377-4331
Angélica N AdamoliServiço de Educação Física e Terapia Ocupacional, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.ORCID http://orcid.org/0000-0002-6594-2520
Daiana C BündchenDepartment of Physiotherapy, Federal University of Santa Catarina, Araranguá, Brazil.ORCID http://orcid.org/0000-0002-3119-6515
Antonio Vinicius SoaresPostgraduate Program in Health and Environment, University of Joinville Region - UNIVILLE, Joinville, Brazil.ORCID http://orcid.org/0000-0001-6090-1423
Rodrigo R KrugUniversity of Cruz Alta, Cruz Alta, Brazil.ORCID http://orcid.org/0000-0002-6701-0751
Maristela BohlkePostgraduate Program in Health and Behavior, Catholic University of Pelotas, Pelotas, Brazil.ORCID http://orcid.org/0000-0001-9372-3475
Antônio J Inda-FilhoFaculty of Medicine, University of Brasilia, Brasília, Brazil.ORCID http://orcid.org/0000-0003-1252-180X
Maycon M ReboredoSchool of Medicine, Federal University of Juiz de Fora, Juiz de Fora, Brazil.ORCID http://orcid.org/0000-0001-8155-7414
Moises WesleyFaculty of Health Sciences, University of Brasilia, Brasília, Brazil.ORCID http://orcid.org/0000-0002-8666-5702
Heitor S RibeiroFaculty of Health Sciences, University of Brasilia, Brasília, Brazil. heitorribeiro@usp.br.ORCID http://orcid.org/0000-0002-4019-4490
SARC-HD Study Group

Funding

Fundação de Apoio à Pesquisa do Distrito Federal 00193-00001833/2023-36
6 · The paper itself

Abstract

backgroundWe investigated the association between polypharmacy and sarcopenia in patients on hemodialysis.

methodsCross-sectional data from the SARC-HD study were analyzed. Patients were classified according to the number of prescribed medications as no polypharmacy (0-4), polypharmacy (5-9), and hyperpolypharmacy (≥ 10). Sarcopenia was diagnosed and staged according to the adapted EWGSOP2 consensus.

results955 patients (48% ≥ 60 years, 61% male) were analyzed. Polypharmacy and hyperpolypharmacy were observed in 50% and 26% of patients, respectively. Patients with hyperpolypharmacy had poorer physical function compared to the no polypharmacy group. Low muscle strength was found in 45%, while sarcopenia (confirmed and severe stages) in 21% of the cohort. Patients in the polypharmacy groups had higher prevalence of low muscle strength, but similar sarcopenia rates to those in the no polypharmacy group. Only hyperpolypharmacy was independently associated with low muscle strength (64% higher adjusted odds, 95% CI 1.10-2.46), whereas no significant associations were observed with sarcopenia. Also, each addition of two medications was independently associated with 10% higher adjusted odds (95% CI 1.02-1.20) of low muscle strength.

conclusionsIn patients on hemodialysis, the number of medications and hyperpolypharmacy were independently associated with low muscle strength, but not with sarcopenia per se.

Indexed as

PolypharmacyRenal DialysisSarcopeniaAgedCross-Sectional StudiesFemaleHumansMaleMiddle AgedMuscle StrengthPrevalenceChronic kidney diseaseDrug therapyEnd-stage kidney diseaseFrailtyHandgrip strengthMedication

Identifiers

PMID40533714
PMCPMC12176980

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.