ArticleJournal of ovarian research2025
Ovarian remodeling and aging-related chronic inflammation and fibrosis in the mammalian ovary.
Article in Journal of ovarian research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- cGAS-STING Signaling as a Molecular Bridge Between Inflammation, Ovarian Ageing, and Reproductive Failure.International journal of molecular sciences · 2026Review
- DNMT/TET Imbalance and Network-Level DNA Methylation Remodeling in Ovarian Aging: Mechanistic Perspectives.Biology · 2026Review
- From Coffee Alkaloid to Ovarian Targets: An Integrated Computational Framework for Trigonelline in Ovarian Aging.Food science & nutrition · 2026Article
- Molecular mechanisms of ovarian fibrosis.Molecular human reproduction · 2026Review
- Ginseng and its active compounds in ovarian aging: mechanistic basis and translational prospects.Frontiers in pharmacology · 2026Review
- The inflammatory clock: how cGAS-STING ticks in the aging ovary.Frontiers in cell and developmental biology · 2026Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundThe female ovary undergoes constant follicular atresia from birth, as well as ovulation and corpus luteum (CL) regression during reproductive age, leading to recurrent ovarian remodeling and ultimately resulting in ovarian aging. However, aging-related cellular and molecular changes in the ovary remain poorly explored.
resultsUsing ovarian transcriptomics, we characterized the changes in gene expression in the ovaries of young (2-month-old), middle-aged (6-month-old) and old (12-month-old) mice. Our analyses revealed that the stromal cell markers THY1 and CD44 were significantly upregulated, whereas the markers of oocytes, granulosa cells and theca cells were markedly downregulated in old mice; thus, endocrine dysfunction occurred. We also found that MAPK pathway- and inflammation response-related genes were enriched and that the populations of Tregs, macrophages and NK cells notably decreased in aged ovaries, which was confirmed by flow cytometry. However, during superovulation, the proportions of macrophages and NK cells steadily increased as the follicles developed and ovulated, whereas the proportion of macrophages sharply decreased after ovulation. We further verified these ovarian changes in specific cell markers and rate-limiting enzymes for steroid hormone synthesis by immunohistochemistry (IHC) and collagen deposition by Masson's trichrome staining in pre- and postmenopausal women.
conclusionsThese results from clinical samples demonstrated that aging-associated changes were similar to those observed in mice and were strongly correlated with the age of the woman. Therefore, this report provides critical insights into aging-related cellular and molecular changes in the ovary.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.