CHEK1 variant is a risk factor for premature ovarian insufficiency by mis- regulating metabolism and inflammation-related genes.

Jianying Guo, Yali Fan, Zifan Song, Lin Li, Meng Fu

Abstract read

In one paragraph

Article in Human genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Double jeopardy: howFrontiers in cell and developmental biology · 2026
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jianying GuoState Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, 100191, China.

Yali FanCentral Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital. Dongcheng, Beijing, 100006, China.

Zifan SongState Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, 100191, China.

Lin LiCentral Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital. Dongcheng, Beijing, 100006, China. linlithu@ccmu.edu.cn.

Meng FuDepartment of Reproductive Medicine, Haidian District Maternal and Child Health Care Hospital, No.53 Suzhou Street, Haidian, Beijing, 100080, China. ameng309@126.com.

Funding

Beijing Hospitals Authority Youth Programme QML20201401National Key Research and Development Program of China 2022YFA0913300National Natural Science Foundation of China 82171628Outstanding Young Talents Program of Capital Medical University B2205Peking University Third Hospital Clinical Key Project BYSY2022054

6 · The paper itself

Abstract

backgroundPremature ovarian insufficiency (POI) is affecting approximately 1% of females and increasingly contributing to female infertility. The etiology of POI is heterogeneous. CHEK1, a critical component of the DNA damage and replication stress response, has recently been linked to female reproductive biology.

resultsWe identified a CHEK1 variant c.77C > G; p.A26G in a POI patient through whole-exome sequencing. Protein structure prediction and pathogenicity analysis suggested that the CHEK1 A26G variant may affect protein stability. RNA sequencing results of 293FT cells overexpressing wild-type and A26G CHEK1 revealed altered expression and alternative splicing of genes involved in metabolism and inflammation.

conclusionCHEK1 may be involved in ovarian aging and the A26G variant may increase susceptibility to POI.

Indexed as

Checkpoint Kinase 1Genetic Predisposition to DiseaseInflammationPrimary Ovarian InsufficiencyAdultAlternative SplicingExome SequencingFemaleHEK293 CellsHumansRisk FactorsCheckpoint Kinase 1CHEK1 protein, humanAssisted reproductionCHEK1MetabolismPremature ovarian insufficiencyVariant

Identifiers

PMID40533835

DOI10.1186/s40246-025-00774-1

PMCPMC12178055

What Socratic holds

Textmetadata

LicenceCC BY

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.