Ilizarov-assisted periosteal distraction for refractory arteriovenous malformation ulcers: first clinical report in Asia.

Xiangyi Wu, Ren Cai, Mao Ye, Xitao Yang, Dachuan Sun, Yifeng Han, Xindong Fan, Jiaxue Zhu

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In one paragraph

Article in Hereditas, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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8 authors.

Xiangyi Wu *Department of Interventional Therapy, Multidisciplinary Team of Vascular Anomalies, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China.

Ren Cai *Department of Interventional Therapy, Multidisciplinary Team of Vascular Anomalies, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China.

Mao YeDepartment of Orthopedics, Fengcheng Hospital Affiliated to Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, Shanghai, PR China.

Xitao YangDepartment of Interventional Therapy, Multidisciplinary Team of Vascular Anomalies, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China.

Dachuan SunDepartment of Orthopedics, Fengcheng Hospital Affiliated to Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, Shanghai, PR China.

Yifeng HanDepartment of Interventional Therapy, Multidisciplinary Team of Vascular Anomalies, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China.

Xindong FanDepartment of Interventional Therapy, Multidisciplinary Team of Vascular Anomalies, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China.

Jiaxue ZhuDepartment of Interventional Therapy, Multidisciplinary Team of Vascular Anomalies, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China. zhuxile521@163.com.

Funding

National Natural Science Foundation of China 82203948

6 · The paper itself

Abstract

Refractory ulcers caused by high-flow arteriovenous malformations (AVMs) pose significant therapeutic challenges due to persistent tissue ischemia and shear stress-induced graft failure. Traditional embolization or flap reconstruction strategies often yield suboptimal outcomes, particularly in weight-bearing regions. We present a 28-year-old female with a non-healing dorsal foot AVM ulcer despite multiple embolizations and radical toe amputations. Genetic testing revealed a KRAS mutation, confirming a somatic etiology of AVM. After a debridement and local flap repair, we employed Ilizarov-assisted periosteal distraction to improve local perfusion. 75% of the wound epithelialized and the infection resolved within 4 weeks postoperatively, with granulation tissue covering the remainder. This case highlights the mechanobiological advantages of Ilizarov-based neovascular stimulation in AVM-related ischemic ulcers.

Indexed as

Arteriovenous MalformationsFoot UlcerIlizarov TechniqueAdultFemaleHumansTreatment OutcomeChemotherapyExtracranial arteriovenous malformationIlizarov techniquePeriosteal distractionUlcer healing

Identifiers

PMID40533860

DOI10.1186/s41065-025-00479-4

PMCPMC12175424

What Socratic holds

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.