ArticleAdvanced healthcare materials2025
High-Throughput 96-Well Nanogroove-Enhanced Electrical Impedance Biosensor for Real-Time Label-Free Cancer Drug Screening.
Article in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Quantitative ICBiosensors · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
This study advances bioelectronic platforms and cellular behavior analysis by enhancing the precision and scalability of nanopatterned membranes integrated with electrode arrays for real-time, high-throughput monitoring. By employing self-assembled monolayers (SAMs) and optimizing imprinting parameters, uniform large-area nanopatterns are successfully fabricated, overcoming challenges such as the "rabbit ears" effect and inconsistent pattern fidelity. The nanopatterned substrates, integrated within 96-well plates with electrode arrays, enable real-time impedance spectroscopy, providing a dynamic assessment of cellular behavior under chemotherapeutic drug exposure. The developed NanoIEA platform facilitates comprehensive investigations into cellular growth and drug interactions. RNA sequencing of MCF-7 cells cultured on nanopatterned substrates reveals significant differential gene expression, suggesting that traditional flat-surface cultures may induce artificial gene regulation, potentially biasing drug screening results. Patterned cell cultures that mimic physiological conditions yield more accurate and predictive outcomes for anticancer drug screening. This research underscores the critical role of nanopatterning in recapitulating in vivo-like gene expression and highlights the profound impact of microenvironmental cues on cellular behavior. By integrating advanced nanofabrication with precise real-time monitoring, this approach addresses technical limitations in bioelectronic sensing while providing deeper insights into dynamic cellular responses, reinforcing the importance of substrate design in tissue engineering and drug development.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.