Evidence map›Paper›PMID 40534311›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025

Longitudinal associations between self-reported exercise levels and cognition in ADAD.

Kelsey R Sewell, James D Doecke, Ralph N Martins, Stephanie R Rainey-Smith, Jeremiah Peiffer, Samantha L Gardener, Hamid R Sohrabi, Kirk I Erickson, Belinda M Brown, Dominantly Inherited Alzheimer Network (DIAN)

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Longitudinal associations between self-reported exercise levels and cognition in ADAD.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kelsey R SewellCentre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, Western Australia, Australia.
James D DoeckeAustralian E-Health Research Centre, CSIRO, Herston, Queensland, Australia.
Ralph N MartinsCentre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.
Stephanie R Rainey-SmithCentre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, Western Australia, Australia.
Jeremiah PeifferCentre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, Western Australia, Australia.
Samantha L GardenerCentre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.
Hamid R SohrabiCentre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, Western Australia, Australia.
Kirk I EricksonAdventHealth Research Institute, Neuroscience, Orlando, Florida, USA.
Belinda M BrownCentre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, Western Australia, Australia.
Dominantly Inherited Alzheimer Network (DIAN)

Funding

Deutsches Zentrum für Neurodegenerative ErkrankungenInstituto de Salud Carlos IIIJapan Agency for Medical Research and DevelopmentKorea Dementia Research CenterKorea Health Industry Development InstituteMinistry of Health & Welfare and Ministry of Science and ICT, Republic of Korea RS-2024-00344521National Health and Medical Research Council (NHMRC) GNT1197315National Institute on Aging (NIA) U19AG032438Raul Carrea Institute for Neurological ResearchThe Alzheimer's Association SG-20-690363-DIANWestern Australian Future Health and Innovation Fund, Government of Western Australia N/A
6 · The paper itself

Abstract

introductionThis study examined longitudinal associations between self-reported exercise and cognition, with moderation by sex, in individuals with autosomal dominant Alzheimer's disease (ADAD) mutations. We also examined whether changes in exercise over time differed in ADAD mutation carriers versus non-carriers in the years preceding first cognitive symptom onset.

methodsParticipants (n = 491) were ADAD mutation carriers (63%) and non-carriers (37%) from the Dominantly Inherited Alzheimer Network aged 37.6 ± 11.1 years. Participants reported their average time partaking in various leisure-time exercise activities over the past 12 months.

resultsGreater baseline exercise predicted better longitudinal cognitive performance. Sex did not moderate these associations. In the years preceding first cognitive symptoms or last follow-up visit, mutation carriers showed a decline in their exercise engagement compared to mutation non-carriers. DISCUSSION: Self-reported exercise is associated with preserved cognitive function in those with ADAD mutations; however, AD-related pathways may influence the level of engagement in exercise prior to cognitive symptom onset. HIGHLIGHTS: Greater weekly exercise predicts slower cognitive decline in ADAD mutation carriers. These associations varied dependent on closeness to estimated symptom onset. These associations were not moderated by sex. Weekly exercise declined in ADAD mutation carriers compared to non-carriers. Results may suggest a bidirectional relationship between exercise and AD risk.

Indexed as

Alzheimer DiseaseCognitionExerciseAdultAgedFemaleHumansLongitudinal StudiesMaleMiddle AgedMutationNeuropsychological TestsSelf Reportautosomal dominant Alzheimer's diseasecognitioncognitive functionexercise

Identifiers

PMID40534311
PMCPMC12177227

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.