Evidence map›Paper›PMID 40534615›Full record

Trial reportJournal of pain research2025

A Multi-Site, Randomized, Parallel-Group, Controlled Trial of Virtually-Delivered Sahaj Samadhi Meditation for the Management of Moderate Depressive Symptoms in Chronic Pain.

Darren K Cheng, Robert Simpson, Rahim Moineddin, Joel Katz, Benoit H Mulsant, Akshya Vasudev, Michelle Greiver, Fardous Hosseiny, Marco Inzitari, Ronnie I Newman and 12 more

Registry-linked trialAbstract readCase ReportsClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of pain research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04039568 (Meditation Versus Education for Improving Depression in Chronic Pain, a Randomized Controlled Trial), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04039568 nacompletednot on this map

Meditation Versus Education for Improving Depression in Chronic Pain, a Randomized Controlled Trial

TypeinterventionalSponsorMount Sinai Hospital, CanadaRan2019 to 2023Enrolled108ConditionsChronic Pain, DepressionArmsHealth Enhancement Program (HEP), Sahaj Samadhi Meditation (SSM)
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Darren K ChengLunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, ON, Canada.ORCID 0000-0002-7819-0938
Robert SimpsonToronto Rehabilitation Institute, University Health Network, Toronto, ON, Canada.
Rahim MoineddinDepartment of Family and Community Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.ORCID 0000-0002-5506-084X
Joel KatzDepartment of Psychology, York University, Toronto, ON, Canada.
Benoit H MulsantDepartment of Psychiatry, University of Toronto, Toronto, ON, Canada.
Akshya VasudevMedpoint Clinic, London, ON, Canada.
Michelle GreiverDepartment of Family and Community Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.ORCID 0000-0001-8957-0285
Fardous HosseinyAtlas Institute for Veterans and Families, Ottawa, ON, Canada.
Marco InzitariREFiT Research Group, Parc Sanitari Pere Virgili and VHIR, Barcelona, Catalonia, Spain.
Ronnie I NewmanArt of Living Foundation, Fort Lauderdale, FL, USA.
Leon RivlinEmergency Medicine, Humber River Health, Toronto, ON, Canada.
Kirk D FoatLunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, ON, Canada.
Andrea D FurlanToronto Rehabilitation Institute, University Health Network, Toronto, ON, Canada.
John Francis FlanneryToronto Rehabilitation Institute, University Health Network, Toronto, ON, Canada.
Deanna TelnerDepartment of Family and Community Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Rachael BosmaToronto Academic Pain Medicine Institute (TAPMI), Women's College Hospital, Toronto, ON, Canada.
Michelle NaimerDepartment of Family and Community Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Chadwick ChungCanadian Memorial Chiropractic College, Toronto, ON, Canada.
Andrew D PintoDepartment of Family and Community Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Michelle L A NelsonLunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, ON, Canada.
Ross UpshurLunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, ON, Canada.
Abhimanyu SudDepartment of Family and Community Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.ORCID 0000-0001-8354-6153

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Chronic pain (CP) often co-occurs with depression, but promising scalable interventions have been under-investigated. We assessed the effectiveness of the virtually-delivered Sahaj Samadhi Meditation (SSM) program in reducing depressive symptoms in people with CP and moderate depressive symptoms. Methods: We conducted a randomized controlled trial comparing SSM to the Health Enhancement Program (HEP), an active control. Participants were recruited from multiple sites in the Greater Toronto Area and virtually. Both 12-week programs were delivered virtually in groups by appropriately trained facilitators. Depressive symptoms were assessed using the Patient Health Questionnaire (PHQ-9) at baseline, 12 weeks, and 24 weeks. ClinicalTrials.gov registration number: NCT04039568. Results: Of 108 participants enrolled, 89 were randomized to SSM (n=43) or HEP (n=46). Between-group differences for the PHQ-9 were not significant. Within-group mean differences for SSM were significant and greater than the minimal clinically important difference at both 12 weeks and 24 weeks (-3.97 (95% CI -6.69 to -1.24) and -4.96 (-8.36 to -1.56), respectively), while within-group mean differences were not significant for HEP. Conclusion: This study suggests potential benefits of SSM for individuals with comorbid CP and depression. Future trials should include larger sample sizes in non-pandemic conditions to better evaluate the effectiveness of SSM. Further research should also explore pragmatic trial designs and the integration of mind-body interventions in clinical settings.

Indexed as

chronic painclinical trialdepressive disordermeditationmind-body therapies

Identifiers

PMID40534615
PMCPMC12174915

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.