ArticleInternational journal of ophthalmology2025
PPARα deficiency exacerbates retinal pathological changes and dysfunction in high-fat diet mice.
Article in International journal of ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
aimTo examined the effects of a high-fat diet (HFD) on retinal pathological changes and dysfunction using peroxisome proliferator-activated receptor-alpha (PPARα) knockout mice.
methodsFor four months, C57BL/6J and
resultsHFD resulted in increased fatty acid β-oxidation in the inner retina, particularly retinal ganglion cells (RGCs), as well as increased weight and accumulation of retinal triglyceride. Retinal fatty acid β-oxidation and triglyceride accumulation were affected by
conclusionIn HFD-fed mice retina, particularly in the inner retina,
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