Evidence map›Paper›PMID 40535023›Full record

ArticleFrontiers in aging2025

Membrane transporter progressive ankylosis protein homologue (

Emma Naomi James, Muy-Teck Teh, Yufeng Li, Christine Wagner-Bock, Zahra Falah Al-Khateeb, Lee Peng Karen-Ng, Terry Roberts, Linnea Synchyshyn, Amy Lewis, Ana O'Loghlen and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Emma Naomi JamesCentre for Oral Immunology and Regenerative Medicine, Institute of Dentistry, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Muy-Teck TehCentre for Oral Immunology and Regenerative Medicine, Institute of Dentistry, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Yufeng LiDepartment of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom.
Christine Wagner-BockUniversitätsklinikum Regensburg, Department of Dermatology, Regensburg, Germany.
Zahra Falah Al-KhateebCentre for Neuroscience, Surgery and Trauma, Blizard Institute, London, United Kingdom.
Lee Peng Karen-NgCentre for Oral Immunology and Regenerative Medicine, Institute of Dentistry, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Terry RobertsDivision of Biosciences, Department of Life Sciences, Centre for Genome Engineering and Maintenance, College of Health and Life Sciences, Brunel University London, Uxbridge, United Kingdom.
Linnea SynchyshynCentre for Oral Immunology and Regenerative Medicine, Institute of Dentistry, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Amy LewisCentre for Genomics and Child Health, Colorectal Cancer Genetics Group, London, United Kingdom.
Ana O'LoghlenCentre for Genomics and Child Health, London, United Kingdom.
Andrew SilverCentre for Genomics and Child Health, Colorectal Cancer Genetics Group, London, United Kingdom.
Adina Teodora Michael-TitusCentre for Neuroscience, Surgery and Trauma, Blizard Institute, London, United Kingdom.
Mark BennettDepartment of Life Sciences, Imperial College London, London, United Kingdom.
Jacob Guy BundyDepartment of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom.
Maria Elzbieta MycielskaDepartment of Structural Biology, Institute of Biophysics and Physical Biochemistry, University of Regensburg, Regensburg, Germany.
Eric Kenneth ParkinsonCentre for Oral Immunology and Regenerative Medicine, Institute of Dentistry, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: A considerable body of recent evidence supports citrate transport as a major regulator of organismal lifespan and healthspan. Citrate accumulates outside senescent cells Methods: EC following various drug and cytokine treatments was measured in human fibroblast and keratinocyte conditioned medium by gas chromatography/mass spectroscopy and liquid chromatography/mass spectroscopy. Membrane transporters in similar human fibroblasts cultures were measured by western blotting and more extensively by reverse transcription and quantitative polymerase chain reaction (qPCR) in human fibroblasts, keratinocytes, myoblasts, adipocytes and astrocytes. Mouse tissues were tested for senescence markers and by qPCR, immunofluorescence and immunoFISH telomere associated foci (TAF) staining. Cytokine levels in conditioned medium were measured by the enzyme-linked immunosorbent assay and in mouse brain tissue and plasma samples using the V-PLEX proinflammatory panel 1 mouse kit. Results and Discussion: We show here that EC is partially mediated by a newly described plasma membrane citrate transporter

Indexed as

ageingANKH/SLC62A1astrocytecitrateinflammationsenescencetelomeretransport

Identifiers

PMID40535023
PMCPMC12174118

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.