ArticleBioinformatics and biology insights2025
Shared Genetic Characteristics of Coronary Artery Disease and Peripheral artery Disease: Insights From Integrated Bioinformatics Analysis of RNA-Sequencing Data.
Article in Bioinformatics and biology insights, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Coronary artery disease (CAD) and peripheral artery disease have serious effects on quality of life. Recent studies have shown that peripheral arterial disorders increase a person's risk of developing CAD. The clinical symptoms of these conditions include palpitations, fatigue, confusion, shortness of breath, and, in severe cases, heart failure or stroke. Despite these similarities, many diseases have no known treatments, which raises grave concerns for world health. The study aims to identify common differentially expressed genes (DEGs) between CAD and peripheral arterial disease (PAD) patients and investigate biological pathways, network-based analysis, immune and inflammatory profiling, biomarker identification, and multi-omics integration. This helps in early detection and targeted treatment strategies. The results revealed 48 upregulated DEGs that were shared among CAD and peripheral arterial disorders. Functional enrichment analysis revealed mainly myofibril assembly and actomyosin organization, highlighting muscle development and cellular structure, and KEGG pathway analysis revealed amino acid metabolism pathways. A network of protein-protein interactions (PPIs) was built via the STRING and visualized by Cytoscape plugin, CytoHubba, and MCODE, which led to the identification of 10 hub genes, ie,
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