Evidence map›Paper›PMID 40535362›Full record

ArticleCureus2025

Myxedema Coma Leading to Acute Coronary Syndrome: A Case Report.

Amir Joshi, Warren Fernandes, Aishwarya Yamparala, Adit M Patel, Saroj K Jha, Nitish Sharma, Richard Wholey

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Amir JoshiInternal Medicine, Saint Vincent Hospital, UMass Chan Medical School, Worcester, USA.
Warren FernandesInternal Medicine, Saint Vincent Hospital, UMass Chan Medical School, Worcester, USA.
Aishwarya YamparalaInternal Medicine, Saint Vincent Hospital, UMass Chan Medical School, Worcester, USA.
Adit M PatelInternal Medicine, Saint Vincent Hospital, UMass Chan Medical School, Worcester, USA.
Saroj K JhaInternal Medicine, Tribhuvan University Teaching Hospital, Kathmandu, NPL.
Nitish SharmaCardiovascular Medicine, Saint Vincent Hospital, UMass Chan Medical School, Worcester, USA.
Richard WholeyCardiovascular Medicine, Saint Vincent Hospital, UMass Chan Medical School, Worcester, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myxedema coma is a rare and life-threatening medical condition. We present a case of poorly controlled hypothyroidism that initially caused myxedema coma and then led to acute coronary syndrome (ACS). A 57-year-old woman with a history of Hashimoto's thyroiditis and coronary artery bypass grafting (CABG) came in with fatigue and worsening left-sided chest pain that occurred even at rest for the past 12 hours. She has not been taking her levothyroxine as prescribed and has not been seeing her endocrinologist for follow-up. When she arrived, her vitals showed that she had a heart rate of 53 beats per minute (sinus bradycardia), but otherwise, she was stable. The laboratory tests showed elevated levels of high sensitivity troponin T at 42 ng/L (normal value: <14 ng/L), a thyroid stimulating hormone level of 408 mIU/L (normal value: 0.5-2.5 mIU/L), a free thyroxine level of 0.4 (normal range: 0.8-1.8 ng/mL), and a decreased glomerular filtration rate of 71 mL/min/1.73 m

Indexed as

acute coronary syndromecase reporthypothyroidismmyocardial infarctionmyxedema coma

Identifiers

PMID40535362
PMCPMC12174829

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.