ArticleFrontiers in aging neuroscience2025
Association between sarcopenic obesity and dementia in the Chinese elderly using different definitions of obesity: evidence from the CHARLS.
Article in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.
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Who cites it
6 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prevalence and Associated Factors of Sarcopenic Obesity in the Community Elderly: Meta-Analysis and Systematic Review.Nutrients · 2026Pooled it
- Association of sarcopenic obesity with cognitive dysfunction and dementia: a systematic review and meta-analysis.Aging clinical and experimental research · 2025Pooled it
- Stage-specific temporal associations between body mass index trajectories and Alzheimer's disease pathologies.European radiology · 2026Article
- Triglyceride-Glucose-Waist-to-Weight Index: Novel Biomarker for Mild Cognitive Impairment in Older People With Sarcopenic Obesity.Journal of cachexia, sarcopenia and muscle · 2026Article
- Sleep Traits and Cognitive Function: A Prospective Cohort Study With Exploration of Inflammatory Biomarkers.Brain and behavior · 2026Article
- Prevalence, influencing factors, and dementia outcome of sarcopenic obesity in China.Aging clinical and experimental research · 2026Article
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Authors and funding
4 authors.
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Abstract
Objectives: The prevalence of sarcopenic obesity, characterized by the coexistence of reduced muscle mass and function alongside increased adipose tissue, is increasing in the aging population. This study aims to investigate the association between sarcopenic obesity and dementia risk in community-dwelling older adults in China, utilizing a nationally representative dataset. Furthermore, we aim to assess the comparative effectiveness of waist circumference versus body mass index as indicators for assessing this risk association. Design: The study was designed as a cross-sectional study. Setting and participants: Based on the nationally representative data from the China Health and Retirement Longitudinal Study (CHARLS) 2015, a total of 5,320 community-dwelling participants aged 60 years and above were categorized into four groups according to their respective classifications of normal status, possible sarcopenia, obesity, and sarcopenic obesity. Methods: Multivariable logistic regression models were used to analyze the relationship between sarcopenic obesity and probable dementia while adjusting for potential confounders. Results: After adjusting for potential confounders, possible sarcopenia alone ( Conclusion and implications: The findings from this cross-sectional study suggest that both possible sarcopenia and sarcopenic obesity are significantly associated with an increased risk of probable dementia among older adults residing in the community in China. Notably, the relationship between sarcopenic obesity and dementia appears to be more pronounced compared to either possible sarcopenia or obesity alone. Moreover, incorporating waist circumference alongside components of possible sarcopenia may serve as a more effective predictor of cognitive impairment when compared to relying solely on body mass index (BMI). These results underscore the critical importance of early identification and intervention for individuals with sarcopenic obesity to mitigate the risk of developing dementia.
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