ReviewFrontiers in cell and developmental biology2025
Role of circadian clock in female embryo implantation.
Review in Frontiers in cell and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Review
- BMAL1 regulates the initial step of embryo implantation by modulating endometrial cell adhesion and migration.Human cell · 2026Article
- Research progress and future directions in circadian rhythms for uterine‑related diseases (Review).Molecular medicine reports · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Accumulating evidence indicates that circadian rhythm disruption can exert an impact on female reproductive function. In the context of female reproduction, the success of embryo implantation is of utmost significance as it is an essential process for female reproduction. Studies have demonstrated that females with disrupted circadian rhythms are more likely to experience embryo implantation failure, which is exemplified by shift workers, nurses, and flight attendants. Therefore, comprehending the circadian rhythm of female embryo implantation is crucial for human reproduction. Herein, we emphasize the mechanism of circadian operation and its regulatory effect on reproductive hormones related to embryo implantation. More importantly, the regulatory role of peripheral clock genes in the process of embryo implantation (endometrial receptivity and decidualization) is highlighted. Finally, melatonin is hypothesized to be a promising treatment for implantation failure caused by circadian rhythm disturbances.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.