ReviewAmerican journal of translational research2025
The relationship between biomechanical factors and intervertebral disc degeneration: a review.
Review in American journal of translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Organ-on-a-Chip Technology: Advances in Modeling Inflammation, Neurovascularization and Nociception in Human Intervertebral Disc Degeneration.Smart medicine · 2026Review
- Stem Cells and their Key Derivatives in Degenerative Musculoskeletal Diseases.Stem cell reviews and reports · 2026Review
- The Degeneration Paradox: Severely Degenerated Cervical Nucleus Pulposus Cells Display Enhanced Mechanoplasticity Under Moderate Cyclic Tensile Strain.Biomolecules · 2026Article
- Cyclic tensile loading regulates nucleus pulposus cell autophagy through mitochondrial dynamics: molecular mechanisms and implications.Journal of translational medicine · 2026Review
- The Biomechanical Landscape of Lumbar Disc Herniation: Mechanobiological Insights Into Injury and Regeneration.Neurospine · 2026Review
- Resetting the epigenetic clock: cellular senescence and regenerative strategies in intervertebral disc degeneration.Frontiers in aging · 2026Review
- Regional Disparities and Divergent Trends in Geriatric Headache, Neck Pain, and Low Back Pain Across Asia-Europe Regions Related to the Belt and Road Corridor.Inquiry : a journal of medical care organization, provision and financingArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The intervertebral disc is an avascular structure composed of the nucleus pulposus, annulus fibrosus, and the superior and inferior cartilage endplates. Located between adjacent vertebrae, it connects them structurally, contributing to spinal stability, load-bearing, shock absorption, and protection of the spinal cord. Intervertebral disc degeneration (IDD) results from various factors, including mechanical overload, trauma, repetitive strain, pregnancy, genetic predisposition, and developmental abnormalities. In the context of increased occupational demands and lifestyle changes, the spine is subjected to greater biomechanical stress, accelerating disc degeneration; increasing the risk of lumbar disc herniation. This review summarizes current knowledge on how biomechanical factors contribute to IDD, focusing on the involvement of mechanical stimuli in cellular and molecular pathways. It highlights both the detrimental and potentially protective effects of biomechanical forces on intervertebral discs and their resident cells. By exploring the dual roles of these forces, this review aims to inform future research directions and therapeutic strategies. Taken together, the evidence underscores a strong relationship between biomechanical loading and intervertebral disc degeneration at both the tissue and cellular levels.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.