ArticleAmerican journal of translational research2025
High platelet distribution width affects the detection of fetal fraction of cell-free DNA detected by non-invasive prenatal testing.
Article in American journal of translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The effect of iron treatment on fetal fraction according to gestational weeks in maternal anemia.Frontiers in medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this study was to investigate the effect of platelet distribution width (PDW) on fetal fraction (FF) of cell-free DNA (cfDNA) within non-invasive prenatal testing (NIPT) during pregnancy.
methodsThe study subjects were pregnant women who voluntarily underwent NIPT and had antenatal examinations at the Affiliated Suzhou Hospital of Nanjing Medical University from January 2016 to January 2021. They underwent routine blood tests before and after NIPT. Univariate and multivariate regression models were used to evaluate the correlation between complete blood count indices and FF.
resultsMultivariate linear regression analysis revealed that hemoglobin (Hb), white blood cell count (WBC), platelet count (PLT), red blood cell distribution width (RDW), PDW, and body mass index (BMI) were negatively correlated with FF, while the interval between the two tests was positively correlated with FF. Notably, PDW (standardized β: -0.097) was the second most significant factor after BMI (standardized β: -0.292). Further grouping by PDW showed that compared to PDW ≤ 12.0 fL, FF decreased by 0.070 (95% CI: -0.111 to -0.030;
conclusionHigher PDW values altered the FF detection, with an observed decrease in FF as PDW levels increased.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.