ArticleAmerican journal of translational research2025
Analysis of serological risk factors for preeclampsia and the predictive role of high homocysteine levels.
Article in American journal of translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Article
- The roles of folate, MTHFR genetics, vitamin B12 in pregnancy outcomes.Frontiers in nutrition · 2026Review
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Authors and funding
3 authors.
Funding
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Abstract
objectivesTo investigate the serological risk factors for preeclampsia, focusing on homocysteine level and its predictive role in the condition.
methodsA retrospective analysis was conducted on 242 pregnant women (121 preeclampsia cases and 121 healthy controls) admitted from January 2022 to June 2023. Serological markers, including homocysteine, fasting blood glucose (FBG), triglycerides (TG), and inflammatory indicators, were compared between the two groups. Statistical analyses, including multivariate logistic regression and receiver operating characteristic (ROC) analysis, were performed to identify significant predictors.
resultsElevated homocysteine levels were strongly associated with preeclampsia, showing a high area under the curve (AUC) of 0.978 in ROC analysis, with a sensitivity of 93.4% and a specificity of 95.0% at a 9.230 μmol/L threshold. TG and FBG were also associated with increased preeclampsia risk, though the latter's significance diminished in multivariate analysis. In terms of inflammatory markers, Interleukin-6 (IL-6) levels were elevated, whereas C-reactive protein (CRP) levels were unexpectedly lower in preeclampsia cases. Lower Vitamin C level was correlated with the presence of preeclampsia.
conclusionElevated homocysteine level was a significant predictor of preeclampsia, alongside dyslipidemia and altered inflammatory responses.
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