ArticleInternational journal of general medicine2025
Spatial Epidemiologic Analysis of Fetal Birth Defects in Guangxi, China.
Article in International journal of general medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To apply various spatial epidemiological approaches to detect spatial trends and geographical clusters of birth defects (BDs) prevalence in Guangxi, China, and to explore the risk factors for BDs. Methods: Between 2016 and 2022, the Guangxi Birth Defects Monitoring Network (GXBDMN) monitored a total of 4.57 million fetuses in this study. The BDs data for fetuses could be obtained from the GXBDMN. The kriging interpolation, spatial autocorrelation, and spatial regression analyses were used to explore the spatial trends patterns, and risk factors of BDs. Results: Between 2016 and 2022, 101,786 fetuses were diagnosed with BDs, resulting in an overall BDs prevalence of 222.68 [95% confidence intervals (CI): 221.33-224.04] per 10,000 fetuses. The global spatial autocorrelation analysis showed a positive spatial autocorrelation in the prevalence of BDs at the county level. The local spatial autocorrelation analysis revealed that the primary clustering patterns of BDs prevalence were High-High and Low-Low. The local indicators of spatial association (LISA) cluster map and kriging interpolation analysis showed that the High-High cluster aggregation areas for the BDs prevalence were gradually shifted from Nanning and Liuzhou to Nanning from 2016 to 2022. The spatial lag model (SLM) results showed that the coefficients of education level (β=15.898, P=0.001), family monthly income per capita (β=0.010, P=0.005) and pre-gestational diabetes mellitus (PGDM)/gestational diabetes mellitus (GDM) (β=10.346, P=0.002) were statistically significant. Conclusion: The spatial trends and geographical cluster patterns of county-level prevalence of BDs in Guangxi are very obvious. Especially, the trend of high clustering in the prevalence of BDs is particularly evident. In addition, BDs are becoming more prevalent due to higher education levels, an increase in family monthly income per capita of pregnant women, and pregnant women with PGDM or GDM.
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