Evidence map›Paper›PMID 40535796›Full record

ArticleResearch and practice in thrombosis and haemostasis2025

Kindlin-3 phosphorylation is crucial for thrombosis and hemostasis

Elzbieta Pluskota, Dorota Szpak, Yunmei Wang, Jun Qin, Daniel I Simon, Edward F Plow, Katarzyna Bialkowska

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Research and practice in thrombosis and haemostasis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Elzbieta PluskotaDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Dorota SzpakDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Yunmei WangCase Cardiovascular Research Institute, Case Western Reserve University School of Medicine and Harrington Heart & Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.
Jun QinDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Daniel I SimonCase Cardiovascular Research Institute, Case Western Reserve University School of Medicine and Harrington Heart & Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.
Edward F PlowDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Katarzyna BialkowskaDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.

Funding

Project 3- Role of Leukocyte-Platelet Interactions in Inflammation and ThrombosisP01HL154811 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI SIMON, DANIEL I · 2021 to 2025
$12.1M
STRUCTURES AND MECHANISMS OF ANK REPEAT BEARING PROTEINSR01HL058758 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI JUN QIN · 1999 to 2026
$9.0M
NHLBI NIH HHS P01 HL154811NHLBI NIH HHS R01 HL058758
6 · The paper itself

Abstract

Background: A single phosphorylation in kindlin-3 at S Objectives: To create a strain of mice expressing kindlin-3 that bears the S Methods: By clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9 gene editing, we generated a mouse strain that expressed a kindlin-3 mutant bearing the S Results: Platelets isolated from S Conclusion: Our observations demonstrate that kindlin-3 phosphorylation on S

Indexed as

hemostasisintegrinkindlin-3plateletsthrombosis

Identifiers

PMID40535796
PMCPMC12175241

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.