Evidence map›Paper›PMID 40536134›Full record

ArticleJournal of surgical oncology2025

Understanding Trends in Incidence and Management of Pregnancy-Associated Breast Cancer in a National Sample Using Claims Data.

Kaamya Varagur, Joseph G Ribaudo, Matthew Keller, Nicholas R Fadell, Cameron Martin, Kevin He, Justin M Sacks, Rebecca Aft, Rachel Anolik, Joani M Christensen

Abstract read
In one paragraph

Article in Journal of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kaamya VaragurDivision of Plastic and Reconstructive Surgery, Washington University in St. Louis, St. Louis, Missouri, USA.ORCID https://orcid.org/0000-0002-2093-5298
Joseph G RibaudoDivision of Plastic and Reconstructive Surgery, Washington University in St. Louis, St. Louis, Missouri, USA.
Matthew KellerInstitute for Informatics, Data Science and Biostatistics, Washington University in St. Louis, St. Louis, Missouri, USA.
Nicholas R FadellDivision of Plastic and Reconstructive Surgery, Washington University in St. Louis, St. Louis, Missouri, USA.
Cameron MartinDivision of Plastic and Reconstructive Surgery, Washington University in St. Louis, St. Louis, Missouri, USA.
Kevin HeDivision of Plastic and Reconstructive Surgery, Washington University in St. Louis, St. Louis, Missouri, USA.
Justin M SacksDivision of Plastic and Reconstructive Surgery, Washington University in St. Louis, St. Louis, Missouri, USA.
Rebecca AftSection of Surgical Oncology, Department of Surgery, Washington University in St. Louis, St. Louis, Missouri, USA.
Rachel AnolikDivision of Plastic and Reconstructive Surgery, Washington University in St. Louis, St. Louis, Missouri, USA.
Joani M ChristensenDivision of Plastic and Reconstructive Surgery, Washington University in St. Louis, St. Louis, Missouri, USA.

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
AHRQ HHS R24 HS019455NCATS NIH HHS UL1 TR002345This study was supported by the Administrative Data Core Services and is supported in part by the Washington University Institute of Clinical and Translational Sciences grant UL1 TR002345 from the National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health (NIH), Washington University Institute of Clinical and Translational Sciences Just-In-Time grant number 986F and 979F, and grant number R24 HS19455 through the Agency for Healthcare Research and Quality (AHRQ).
6 · The paper itself

Abstract

BACKGROUND AND

objectivesBreast cancer incidence in young women is increasing globally. Here, we examine trends in incidence, management, and reconstruction for pregnancy-associated breast cancer (PABC) in women 18-45.

methodsFemales aged 18-45 with breast cancer between 2007 and 2021 were identified in the Merative MarketScan Commercial and Multi-State Medicaid Databases. We analyzed trends in incidence of PABC, treatments, and latency to treatments for PABC versus non-PABC.

resultsA total of 1189 patients with PABC and 36 683 with non-PABC were included. Over the study period, the proportion of breast cancer cases classified as PABC increased (2.36% of cases from 2007 to 2009, to 3.94% from 2019 to 2021; p < 0.001). Patients with PABC experienced higher rates of neoadjuvant chemotherapy, mastectomy, trastuzumab, and ovarian suppression therapy than patients with non-PABC, and lower rates of adjuvant radiation and breast conserving surgery (p ≤ 0.001). PABC status did not independently predict increased latency from diagnosis to tumor resection surgery when controlling for receipt of neoadjuvant chemotherapy (p = 0.154). Patients with PABC experienced comparable rates of delayed or immediate implant and autologous reconstruction as patients with non-PABC, but experienced increased latency to delayed implant reconstruction (p < 0.001).

conclusionsPABC rates are increasing among women 45 and younger. Patients with PABC experience differences in types of medical/surgical treatments received and timing of post-mastectomy reconstruction.

Indexed as

Breast NeoplasmsPregnancy Complications, NeoplasticAdolescentAdultDatabases, FactualFemaleFollow-Up StudiesHumansIncidenceMammaplastyMastectomyMiddle AgedPregnancyUnited StatesYoung Adultbreast cancer incidencebreast cancer treatmentbreast‐conserving surgerybreast reconstructionmastectomypregnancy‐associated breast cancer

Identifiers

PMID40536134
PMCPMC12633760

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.