Evidence map›Paper›PMID 40536655›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025

Case report of ischemic stroke in a child secondary to neuroborreliosis.

Dawid Zakrzewski, Mateusz Tomkiewicz, Wiktoria Kubziakowska, Marta Zawadzka, Jakub Szymarek, Maria Mazurkiewicz-Bełdzińska

Abstract readCase Reports
In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dawid ZakrzewskiDepartment of Developmental Neurology, Medical University of Gdansk, 80-210, Gdansk, Poland.ORCID http://orcid.org/0000-0002-8265-5232
Mateusz TomkiewiczDepartment of Developmental Neurology, Medical University of Gdansk, 80-210, Gdansk, Poland.ORCID http://orcid.org/0009-0002-6567-1692
Wiktoria KubziakowskaDepartment of Developmental Neurology, Medical University of Gdansk, 80-210, Gdansk, Poland.
Marta ZawadzkaDepartment of Developmental Neurology, Medical University of Gdansk, 80-210, Gdansk, Poland. marta.zawadzka@gumed.edu.pl.ORCID http://orcid.org/0000-0003-4562-1882
Jakub SzymarekDepartment of Developmental Neurology, Medical University of Gdansk, 80-210, Gdansk, Poland.
Maria Mazurkiewicz-BełdzińskaDepartment of Developmental Neurology, Medical University of Gdansk, 80-210, Gdansk, Poland.ORCID http://orcid.org/0000-0002-9405-5066

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNeuroborreliosis is a neurological manifestation resulting from bacteria of the Borrelia burgdorferi sensu lato complex infection. This condition presents with a range of heterogeneous symptoms affecting the central and peripheral nervous systems, manifesting with varying frequency in adults and children. In rare cases, the infection may lead to ischemic stroke, however the pathogenesis remains incompletely understood due to its infrequent occurrence. The development of ischemic stroke in these patients is likely mediated by arterial inflammation, leading to critical narrowing of blood vessels and subsequently to ischemia. CASE PRESENTATION: This paper presents the case of a 16-year-old patient diagnosed with ischemic stroke. The patient was treated with enoxaparin until exclusion of cardioembolism and vascular dissection. After excluding other potential causes, neuroborreliosis was considered highly probable due to a history of multiple tick bites and elevated titers of antibodies against Borrelia burgdorferi in both blood serum and cerebrospinal fluid. Therefore, the patient received antibiotic therapy. In long-term follow-up, he has shown significant improvement, returning to his pre-stroke level of function.

conclusionsThe lack of literature on the subject contributes to the diagnostic and therapeutic challenges in affected patients. The patient's condition improved as a result of early recognition and prompt initiation of treatment and rehabilitation. It is becoming increasingly important to differentiate paediatric patients with a diagnosis of ischemic stroke also with regard to neuroborreliosis in endemic regions.

Indexed as

Ischemic StrokeLyme NeuroborreliosisAdolescentAnti-Bacterial AgentsHumansMaleAnti-Bacterial AgentsChilds neuroborreliosisIschemic stroke in childrenLyme diseaseNeuroborreliosisStroke in children

Identifiers

PMID40536655
PMCPMC12394360

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.