Evidence map›Paper›PMID 40536979›Full record

ArticleScience (New York, N.Y.)2025

Sleep need-dependent plasticity of a thalamic circuit promotes homeostatic recovery sleep.

Sang Soo Lee, Qiang Liu, Alexandra H R Cheng, Dong Won Kim, Daphne M Boudreau, Anuradha Mehta, Mehmet F Keles, Rafal Fejfer, Isabelle Palmer, Kristen H Park and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. [Correlations of calmodulin and neurotransmitters with polysomnographic parameters in patients with chronic insomnia disorder].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. The Beauty Sleep to Keep a Healthy Liver.International journal of molecular sciences · 2025
    Review
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Sang Soo LeeDepartment of Neurology, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0003-0467-9025
Qiang LiuDepartment of Neurology, Johns Hopkins University, Baltimore, MD, USA.ORCID 0009-0000-6979-066X
Alexandra H R ChengDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.ORCID 0009-0000-1856-6123
Dong Won KimSolomon H. Snyder Department of Neuroscience, Johns Hopkins University, MD, USA.ORCID 0000-0001-8624-0168
Daphne M BoudreauDepartment of Neurology, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0003-4336-8561
Anuradha MehtaDepartment of Neurology, Johns Hopkins University, Baltimore, MD, USA.
Mehmet F KelesDepartment of Neurology, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0001-6673-1613
Rafal FejferSolomon H. Snyder Department of Neuroscience, Johns Hopkins University, MD, USA.ORCID 0009-0000-7649-7971
Isabelle PalmerDepartment of Neurology, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0001-5676-4737
Kristen H ParkDepartment of Neurology, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0002-7496-772X
Heike MünzbergPennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA.ORCID 0000-0002-1152-4884
Timothy D HarrisDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0002-6289-4439
Austin R GravesDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0003-1087-3684
Seth BlackshawSolomon H. Snyder Department of Neuroscience, Johns Hopkins University, MD, USA.ORCID 0000-0002-1338-8476
Mark N WuDepartment of Neurology, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0002-1329-0655

Funding

Neuropixels NXT: Integrated Silicon Probes for Large Scale Extracellular Recording in Rodents and PrimatesU01NS115587 · NINDS · JOHNS HOPKINS UNIVERSITY · PI HARRIS, TIMOTHY D · 2020 to 2024
$13.1M
Murine Mutagenesis CoreP30NS050274 · NINDS · JOHNS HOPKINS UNIVERSITY · PI KOLODKIN, ALEX L · 2005 to 2020
$10.9M
Cross-Species Analyses of the Molecular and Circuit Basis ofSleepR35NS122181 · NINDS · JOHNS HOPKINS UNIVERSITY · PI Mark N Wu · 2021 to 2026
$6.9M
Molecular and Cellular Mechanisms Underlying the Circadian Timing of SleepR01NS094571 · NINDS · JOHNS HOPKINS UNIVERSITY · PI WU, MARK N · 2016 to 2020
$2.5M
Development and function of hypothalamic Lhx6-positive neuronsR01MH126676 · NIMH · JOHNS HOPKINS UNIVERSITY · PI BLACKSHAW, SETH · 2021 to 2025
$2.0M
LSM880 Laser-scanning Microscope with Airyscan ModuleS10OD023548 · OD · JOHNS HOPKINS UNIVERSITY · PI KUO, SCOT CHARLES · 2018 to 2018
$439k
NIH HHS S10 OD023548NIMH NIH HHS R01 MH126676NINDS NIH HHS P30 NS050274NINDS NIH HHS R01 NS094571NINDS NIH HHS R35 NS122181NINDS NIH HHS U01 NS115587
6 · The paper itself

Abstract

Prolonged wakefulness leads to persistent, deep recovery sleep (RS). However, the neuronal circuits that mediate this process remain elusive. From a circuit screen in mice, we identified a group of thalamic nucleus reuniens (RE) neurons activated during sleep deprivation (SD) and required for sleep homeostasis. Optogenetic activation of RE neurons leads to an unusual phenotype: presleep behaviors (grooming and nest organizing) followed by prolonged, intense sleep that resembles RS. Inhibiting RE activity during SD impairs subsequent RS, which suggests that these neurons signal sleep need. RE neurons act upstream of sleep-promoting zona incerta cells, and SD triggers plasticity of this circuit to strengthen their connectivity. These findings reveal a circuit mechanism by which sleep need transforms the functional coupling of a sleep circuit to promote persistent, deep sleep.

Indexed as

HomeostasisMidline Thalamic NucleiNeuronal PlasticityNeuronsSleep DeprivationSleep, Slow-WaveAnimalsMaleMiceMice, Inbred C57BLOptogeneticsWakefulness

Identifiers

PMID40536979
PMCPMC12315381

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.