SynthesisTranslational psychiatry2025
Multi-ancestry genome-wide association analyses incorporating SNP-by-psychosocial interactions identify novel loci for serum lipids.
Abstract readMeta-Analysis
In one paragraph
Synthesis in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
132 authors.
Amy R Bentley *Center for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, MD, 20892, USA. amy.bentley@nih.gov.ORCID http://orcid.org/0000-0002-0827-9101
Michael R Brown *Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.ORCID http://orcid.org/0000-0002-5235-9037
Solomon K MusaniMerexAgRight Farm, Ltd., Kitale, Kenya.
Karen L SchwanderDivision of Statistical Genomics, Washington University, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-0193-4134
Thomas W WinklerDepartment of Epidemiology, University of Regensburg, Regensburg, 93051, Germany.ORCID http://orcid.org/0000-0003-0292-5421
Mario SimsDepartment of Social Medicine, Population and Public Health, University of California, Riverside School of Medicine, Riverside, CA, 92521, USA.
Tuomas O KilpeläinenNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, DK-2200, Denmark.ORCID http://orcid.org/0000-0002-8349-3028
Hugues AschardInstitut Pasteur, Université Paris Cité, Department of Computational Biology, F-75015, Paris, France.ORCID http://orcid.org/0000-0002-7554-6783
Traci M BartzDepartment of Biostatistics, University of Washington, Seattle, WA, 98101, USA.
Lawrence F BielakDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID http://orcid.org/0000-0002-3443-8030
Jin-Fang ChaiSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore, 117549, Singapore.
Kumaraswamy Naidu ChitralaDepartment of Engineering Technology, University of Houston, Sugar Land, TX, 77479, USA.
Nora FranceschiniDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC, 27516, USA.ORCID http://orcid.org/0009-0001-8346-3662
Mariaelisa GraffDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC, 27516, USA.ORCID http://orcid.org/0000-0001-6380-1735
Xiuqing GuoDepartment of Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.ORCID http://orcid.org/0000-0002-5264-5068
Fernando P HartwigDepartment of Epidemiology, Federal University of Pelotas, Pelotas, RS, 96020-220, Brazil.ORCID http://orcid.org/0000-0003-3729-0710
Andrea R V R HorimotoDepartment of Biostatistics, University of Washington, Seattle, WA, 98101, USA.
Elise LimDepartment of Biostatistics, Boston University, Boston, MA, 02118, USA.ORCID http://orcid.org/0000-0001-8967-8464
Yongmei LiuDepartment of Medicine, Division of Cardiology, Duke University School of Medicine, Durham, NC, 27701-2047, USA.
Alisa K ManningClinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA, 02114, USA.ORCID http://orcid.org/0000-0003-0247-902X
Ilja M NolteDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9713 GZ, The Netherlands.ORCID http://orcid.org/0000-0001-5047-4077
Raymond NoordamDepartment of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, 2333ZA, the Netherlands.ORCID http://orcid.org/0000-0001-7801-809X
Melissa A RichardMcGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
Albert V SmithDepartment of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID http://orcid.org/0000-0003-1942-5845
Yun Ju SungDivision of Biostatistics, Washington University, St. Louis, MO, 63110, USA.ORCID http://orcid.org/0000-0002-8021-4070
Dina VojinovicDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Rujia WangSocial, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Yujie WangDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC, 27516, USA.ORCID http://orcid.org/0000-0002-1087-2182
Mary F FeitosaDivision of Statistical Genomics, Washington University, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-0933-2410
Sarah E HarrisLothian Birth Cohorts, Department of Psychology, The University of Edinburgh, Edinburgh, EH8 9JZ, UK.ORCID http://orcid.org/0000-0002-4941-5106
Leo-Pekka LyytikäinenDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, 33520, Finland.ORCID http://orcid.org/0000-0002-7200-5455
Giorgio PistisDepartment of Psychiatry, Lausanne University Hospital and University of Lausanne, Prilly, Vaud, 1008, Switzerland.ORCID http://orcid.org/0000-0002-4525-4608
Rainer RauramaaFoundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, 70100, Finland.
Peter J van der MostDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9713 GZ, The Netherlands.ORCID http://orcid.org/0000-0001-8450-3518
Erin WareSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48104, USA.ORCID http://orcid.org/0000-0003-4731-8158
Stefan WeissInterfaculty Institute of Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, 17489, Germany.ORCID http://orcid.org/0000-0002-3553-4315
Wanqing WenDivision of Epidemiology, Vanderbilt University Medical Center, Nashville, TN, 37203, USA.
Lisa R YanekDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.ORCID http://orcid.org/0000-0001-7117-1075
Dan E ArkingMcKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.ORCID http://orcid.org/0000-0001-8980-8695
Donna K ArnettDepartment of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, 29169, USA.
Christie BallantyneSection of Cardiovascular Research, Baylor College of Medicine, Houston, TX, 77030, USA.ORCID http://orcid.org/0000-0002-6432-1730
Eric BoerwinkleDepartment of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
Yii-Der Ida ChenDepartment of Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.
Martha L DaviglusInstitute for Minority Health Research, University of Illinois Chicago, Chicago, IL, 60612, USA.
Lisa de Las FuentesCenter for Biostatistics and Data Science, Institute for Informatics, Data Science, and Biostatistics (I2BD), Washington University School of Medicine, St. Louis, MO, 63110, USA.ORCID http://orcid.org/0000-0002-4689-325X
Paul S de VriesDepartment of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.ORCID http://orcid.org/0000-0003-0964-0111
Joseph A C DelaneyDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
Amanda M FrettsDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
Lynette EkunweDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS, 39213, USA.
Jessica D FaulSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48104, USA.
Linda C GalloDepartment of Psychology, San Diego State University, San Diego, CA, USA.
Sami HeikkinenInstitute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, Kuopio, 70100, Finland.ORCID http://orcid.org/0000-0002-6083-2402
Georg HomuthInterfaculty Institute of Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, 17489, Germany.
M Arfan IkramDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0003-0372-8585
Carmen R IsasiDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.ORCID http://orcid.org/0000-0003-2700-9593
Jost Bruno JonasInstitute of Molecular and Clinical Ophthalmology Basel IOB, Basel, Switzerland.ORCID http://orcid.org/0000-0003-2972-5227
Liisa Keltikangas-JärvinenDepartment of Psychology and Logopedics, University of Helsinki, Helsinki, 00014, Finland.ORCID http://orcid.org/0000-0002-7977-3852
Pirjo KomulainenFoundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, 70100, Finland.
Aldi T KrajaUniversity of Mississippi Medical Center, Jackson, MS, 39213, USA.
Jose E KriegerHeart Institute (InCor), University of São Paulo Medical School, São Paulo, SP, 05403-900, Brazil.ORCID http://orcid.org/0000-0001-5464-1792
Lenore LaunerLaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA.ORCID http://orcid.org/0000-0002-3238-7612
Lifelines Cohort Study
Jianjun LiuGenome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore, 138672, Singapore.ORCID http://orcid.org/0000-0002-3255-3019
Kurt LohmanDepartment of Medicine, Duke Molecular Physiology Institute Duke University School of Medicine, Durham, NC, 27701-2047, USA.
Annemarie I LuikDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0001-7517-197X
Ani W ManichaikulCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, 22908, USA.ORCID http://orcid.org/0000-0002-5998-795X
Pedro Marques-VidalDepartment of Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne, Rue du Bugnon 46, CH- 1011, Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-4548-8500
Yuri MilaneschiDepartment of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, 1081 HJ, the Netherlands.ORCID http://orcid.org/0000-0002-3697-6617
Stanford E MwasongweVeritas Management Group, Inc., Alpharetta, GA, 30072, USA.
Jeffrey R O'ConnellDivision of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA.
Kenneth RiceDepartment of Biostatistics, University of Washington, Seattle, WA, 98101, USA.
Stephen S RichCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, 22908, USA.ORCID http://orcid.org/0000-0003-3872-7793
Pamela J SchreinerDivision of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA.
Lars SchwettmannDepartment of Health Services Research, School of Medicine and Health Services, Carl von Ossietzky Universität Oldenburg, Oldenburg, 26111, Germany.
James M ShikanyDivision of Preventive Medicine, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35205, USA.
Xiao-Ou ShuDivision of Epidemiology, Vanderbilt University Medical Center, Nashville, TN, 37203, USA.
Jennifer A SmithDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID http://orcid.org/0000-0002-3575-5468
Harold SniederDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9713 GZ, The Netherlands.ORCID http://orcid.org/0000-0003-1949-2298
Nona SotoodehniaCardiovascular Health Research Unit, Division of Cardiology, University of Washington, Seattle, Washington, 98195, USA.
E Shyong TaiYong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore, 119228, Singapore.ORCID http://orcid.org/0000-0003-2929-8966
Kent D TaylorDepartment of Pediatrics, LA Biomed at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.ORCID http://orcid.org/0000-0002-2756-4370
Lesley TinkerPublic Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA.ORCID http://orcid.org/0000-0003-2469-1929
Michael Y TsaiLaboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, 55455, USA.
André G UitterlindenDepartment of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-7276-3387
Cornelia M van DuijnDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0002-2374-9204
Diana van HeemstDepartment of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, 2333ZA, the Netherlands.
Melanie WaldenbergerResearch Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, 85764, Germany.ORCID http://orcid.org/0000-0003-0583-5093
Robert B WallaceDepartment of Epidemiology, University of Iowa College of Public Health, Iowa City, IA, USA.
Hwee-Lin WeeSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore, 117549, Singapore.
David R WeirSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48104, USA.ORCID http://orcid.org/0000-0002-1661-2402
Wen-Bin WeiBeijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Ko Willems van DijkDepartment of Human Genetics, Leiden University Medical Center, Leiden, 2333ZA, The Netherlands.ORCID http://orcid.org/0000-0002-2172-7394
Gregory WilsonSchool of Public Health, Jackson State University, Jackson, MS, 39213, USA.
Jie YaoDepartment of Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.
Kristin L YoungDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC, 27516, USA.ORCID http://orcid.org/0000-0003-0070-6145
Xiaoyu ZhangDepartment of Biostatistics, Boston University, Boston, MA, 02118, USA.
Wei ZhaoDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID http://orcid.org/0000-0001-7388-0692
Xiaofeng ZhuDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, 44106, USA.ORCID http://orcid.org/0000-0003-0037-411X
Alan B ZondermanLaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA.ORCID http://orcid.org/0000-0002-6523-4778
Ian J DearyLothian Birth Cohorts, Department of Psychology, The University of Edinburgh, Edinburgh, EH8 9JZ, UK.ORCID http://orcid.org/0000-0002-1733-263X
Christian GiegerResearch Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, 85764, Germany.ORCID http://orcid.org/0000-0001-6986-9554
Hans Jörgen GrabeGerman Centre for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, 17475, Germany.
Timo A LakkaFoundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, 70100, Finland.ORCID http://orcid.org/0000-0002-9199-2871
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, 33520, Finland.ORCID http://orcid.org/0000-0002-2555-4427
Albertine J OldehinkelDepartment of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, 9713 GZ, the Netherlands.ORCID http://orcid.org/0000-0003-3925-3913
Martin PreisigDepartment of Psychiatry, Lausanne University Hospital and University of Lausanne, Prilly, Vaud, 1008, Switzerland.ORCID http://orcid.org/0000-0001-5689-4259
Ya-Xing WangBeijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Hospital, Capital Medical University, Beijing, China.ORCID http://orcid.org/0000-0003-2749-7793
Wei ZhengDivision of Epidemiology, Vanderbilt University Medical Center, Nashville, TN, 37203, USA.
Michele K EvansLaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA.
Michael ProvinceDivision of Statistical Genomics, Washington University, St. Louis, MO, USA.ORCID http://orcid.org/0000-0001-6102-774X
James GaudermanDivision of Biostatistics, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, 90032, USA.
Vilmundur GudnasonIcelandic Heart Association, Icelandic Heart Association, Kópavogur, 201, Iceland.ORCID http://orcid.org/0000-0001-5696-0084
Catharina A HartmanDepartment of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, 9713 GZ, the Netherlands.ORCID http://orcid.org/0000-0002-8094-8859
Bernardo L HortaPostgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, RS, 96020-220, Brazil.ORCID http://orcid.org/0000-0001-9843-412X
Sharon L R KardiaDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.
Charles KooperbergPublic Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA.ORCID http://orcid.org/0000-0002-7986-8560
Ching-Ti LiuDepartment of Biostatistics, Boston University, Boston, MA, 02118, USA.ORCID http://orcid.org/0000-0002-0703-0742
Dennis O Mook-KanamoriDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2333ZA, the Netherlands.
Brenda Wjh PenninxDepartment of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, 1081 HJ, the Netherlands.ORCID http://orcid.org/0000-0001-7779-9672
Alexandre C PereiraHeart Institute (InCor), University of São Paulo Medical School, São Paulo, SP, 05403-900, Brazil.ORCID http://orcid.org/0000-0002-7782-5540
Patricia A PeyserDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID http://orcid.org/0000-0002-9717-8459
Bruce M PsatyCardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Systems and Population Health, University of Washington, Seattle, USA.ORCID http://orcid.org/0000-0002-7278-2190
Jerome I RotterDepartment of Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.ORCID http://orcid.org/0000-0001-7191-1723
Xueling SimSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore, 117549, Singapore.ORCID http://orcid.org/0000-0002-1233-7642
Kari E NorthDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC, 27516, USA.ORCID http://orcid.org/0000-0002-8903-0366
Dabeeru C RaoCenter for Biostatistics and Data Science, Institute for Informatics, Data Science, and Biostatistics (I2BD), Washington University School of Medicine, St. Louis, MO, 63110, USA.
Laura BierutDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, 63110, USA.ORCID http://orcid.org/0000-0002-9952-4810
Clint L MillerCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, 22908, USA.ORCID http://orcid.org/0000-0003-4276-3607
Alanna C MorrisonDepartment of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.ORCID http://orcid.org/0000-0001-6381-4296
Charles N Rotimi *Center for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, MD, 20892, USA.ORCID http://orcid.org/0000-0001-5759-053X
Myriam Fornage *McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.ORCID http://orcid.org/0000-0003-0677-8158
Ervin R Fox *Department of Medicine, University of Mississippi Medical Center, Jackson, MS, 39213, USA.
Funding
Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI HANS-JOACHIM LEHMLER · 1990 to 2026
$40.5MStatistical Methods for Integrative Genomics in CancerP01CA196569 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KIMBERLY D SIEGMUND · 2016 to 2026
$25.5MPilot Program CoreP30ES027792 · NIEHS · UNIVERSITY OF CHICAGO · PI Gokhan M. Mutlu, Gail S Prins · 2017 to 2026
$13.6MA Multi-Ancestry Study of Gene-Lifestyle Interactions and Multi-Omics in Cardiometabolic TraitsR01HL156991 · NHLBI · WASHINGTON UNIVERSITY · PI RAO, DABEERU C · 2021 to 2024
$8.8MA Multi-Ethnic Study of Gene-Lifestyle Interactions in Cardiovascular TraitsR01HL118305 · NHLBI · WASHINGTON UNIVERSITY · PI RAO, DABEERU C · 2014 to 2017
$8.3MInfrastructure for mentored access to CHS data and specimensR01HL172803 · NHLBI · UNIVERSITY OF WASHINGTON · PI James S Floyd, Michelle Christina Odden · 2025 to 2026
$2.7MGenetic epidemiology of complex diseasesZ01HG200362 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI ROTIMI, CHARLES · 2008 to 2008
$1.7MIntramural NIH HHS Z01 HG200362NCI NIH HHS P01 CA196569NHLBI NIH HHS R01 HL118305NHLBI NIH HHS R01 HL156991NHLBI NIH HHS R01 HL172803NIEHS NIH HHS P30 ES005605NIEHS NIH HHS P30 ES027792U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (NHGRI) Z01HG200362
Abstract
Serum lipid levels, which are influenced by both genetic and environmental factors, are key determinants of cardiometabolic health and are influenced by both genetic and environmental factors. Improving our understanding of their underlying biological mechanisms can have important public health and therapeutic implications. Although psychosocial factors, including depression, anxiety, and perceived social support, are associated with serum lipid levels, it is unknown if they modify the effect of genetic loci that influence lipids. We conducted a genome-wide gene-by-psychosocial factor interaction (G×Psy) study in up to 133,157 individuals to evaluate if G×Psy influences serum lipid levels. We conducted a two-stage meta-analysis of G×Psy using both a one-degree of freedom (1df) interaction test and a joint 2df test of the main and interaction effects. In Stage 1, we performed G×Psy analyses on up to 77,413 individuals and promising associations (P < 10
Indexed as
Gene-Environment InteractionGenome-Wide Association StudyLipidsAdultFemaleGenetic LociHumansMaleMiddle AgedPolymorphism, Single NucleotideSocial SupportLipids
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.