ArticleCommunications biology2025
Exercise improves depressive-like behavior in adolescent mice by regulating sphingosine and ceramide metabolism through microglial CerS1.
Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Aerobic exercise for depression symptoms in adolescents: a systematic review and dose-response meta-analysis.BMC public health · 2026Pooled it
- Metabolic Reprogramming of Microglia in Neuroinflammation and Depression.International journal of molecular sciences · 2026Review
- Exercise-conditioned extracellular vesicles in Alzheimer's disease: a multi-organ signaling network linking peripheral adaptation to brain pathology.Frontiers in immunology · 2026Review
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Authors and funding
11 authors.
Funding
Abstract
Given the unique onset period of adolescent depression, it is crucial to prioritize treatment modalities that are not only effective but also carry low side effects and promote overall health, with exercise emerging as a notable option. High-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) stand out as two prominent forms of exercise, proven to be beneficial in addressing a multitude of disorders. Microglia mediated neuroinflammation is one of the main hypotheses leading to depression. Neuroinflammation leads to abnormal synaptic function, impaired neuroplasticity, and ultimately depressive symptoms. However, the exact mechanisms of exercise in microglia and adolescent depression remain unclear. In this study, we found that exercise can increase the expression of microglial ceramide synthase 1 (CerS1), promote the synthesis of C18 ceramide from sphingosine, and improve depressive-like behaviors in adolescent mice. Overexpression of CerS1 in the CA1 region using microglia specific adeno-associated virus (AAV) inhibits chronic unpredictable mild stress (CUMS) induced neuroinflammation. Meanwhile, overexpression of CerS1 in primary microglia inhibits lipopolysaccharide (LPS) induced neuroinflammation. These results provide new theoretical support for the treatment of adolescent depression with exercise from the perspective of animal models.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.