Trial reportEuropean journal of applied physiology2025
Cytokine and adipokine response following high-intensity interval running and cycling in female adolescents.
Trial report in European journal of applied physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Acute Cytokine Responses to High-Intensity Intermittent Exercise in Humans: A Systematic Review.International journal of molecular sciences · 2026Pooled it
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
The purpose of this study was to compare the response of cytokines, and adipokines to high-intensity interval running (HIIR) versus cycling (HIIC) in female adolescents. Eleven untrained adolescent females at post-peak height velocity, aged 15-19 years, performed two trials (HIIR and HIIC) in a randomised order. Each participant performed a progressive incremental test for each mode of exercise to determine the > 90% max workload for the trials. The trials consisted of 8 bouts of 1 min of running or cycling at > 90% maximal workload with 1 min of passive recovery in between bouts. Blood samples were collected pre-exercise, 5- and 60-min post-exercise. Pro-inflammatory TNF-α, anti-inflammatory IL-10, IL-6 (pro-/anti-inflammatory), leptin and adiponectin were measured in serum. IL-6 increased at 5 min (time-effect: β = 0.656 ± - 0.277, p = 0.032) and 60 min following exercise compared to pre-exercise (time-effect: β = 1.036 ± 0.277, p = 0.001) in both trials. IL-10 started to increase immediately after exercise (time effect: β = 0.170 ± 0.069, p = 0.025) and peaked 60 min after exercise compared to pre-exercise (time effect: β = 0.317 ± 0.069, p < 0.001). TNF-α concentrations peaked 5 min only after HIIR (interaction effect: β = 2.777, p < 0.001). No change was observed in the IL-6/IL-10 ratio, but a significant decrease was observed in the TNF-α/IL-10 ratio 60 min post-exercise (time effect: β = - 0.269 ± 0.070, p = 0.001). Leptin decreased 60 min post-exercise compared to pre-exercise in both modes (time-effect: β = 0.155 ± 0.505, p = 0.004). No change was observed in adiponectin and the adiponectin/leptin ratio. In female adolescents, high-intensity interval exercise induces an immediate, transient pro-inflammatory response accompanied by a delayed increase in anti-inflammatory cytokines and leptin, irrespective of exercise mode.
Indexed as
Identifiers
40537575What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.