ArticleMolecular neurobiology2025
Single-Cell Transcriptome Patterns of Transposable Elements in Alzheimer's Disease.
Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Reading the SINEs - functionality in noncoding RNA 'cheap genes'.RNA biology · 2026Review
- Distinct Transposable Element Transcript Patterns in Microglia Across Aging and Alzheimer's Disease.Aging cell · 2026Article
- Transcriptomic Evidence of Mitochondrial Double-Stranded RNA Accumulation in Brain Aging and Alzheimer's Disease.Aging cell · 2026Article
- Modern Mining: The Role of Single-cell RNA Sequencing in Advancing Neuroscience Research.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Growing evidence implicates transcripts from transposable elements (TEs) in the pathogenesis of Alzheimer's disease (AD). However, despite recent single-cell/nucleus RNA sequencing (sc/snRNA-seq) studies of AD, cell type-specific patterns in TE transcripts have not been reported. Therefore, we examined TE transcripts in snRNA-seq datasets based on prefrontal cortex samples from AD patients. We analyzed gene/TE expression in 143,951 cells and found that: (1) TE transcripts are broadly increased with AD in most brain cell types; (2) retrotransposon transcripts are most increased with AD pathology in excitatory neurons; and (3) TE loci are more transcriptionally accessible in AD, especially in neurons/excitatory neurons. We also confirmed our findings in complementary analyses of bulk RNA-seq data on AD. Together, our data provide novel insight into TE transcript dynamics across different cell types in the AD brain.
Indexed as
Identifiers
40537665What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.