ReviewJournal of translational medicine2025
Functions and mechanisms of lncRNAs in immune escape and their application in immunotherapy for colorectal cancer.
Review in Journal of translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Therapeutic modulation of HIV-1 using miRNAs and lncRNAs: from bench to bedside.Virology journal · 2026Review
- The Oncogenic Role of Long Non-Coding RNABiology · 2026Review
- Genomic innovations in cancer prevention, diagnosis, prognosis and precision therapeutics.Frontiers in genetics · 2026Review
- Long non-coding RNAs in the crosstalk between diabetes and colorectal cancer: molecular mechanisms and endocrine pathways.Frontiers in molecular biosciences · 2026Review
- Epigenetics of Malignant Melanoma: Mechanisms, Diagnostic Approaches and Therapeutic Applications.Oncology research · 2026Review
- Long non-coding RNAs and VEGF in ovarian cancer: mechanisms and therapeutic potential.Journal of ovarian research · 2025Review
- Regulatory roles of LncRNAs in colorectal cancer immune evasion: current concepts and future perspectives.Discover oncology · 2025Review
- The Interplay Between lncRNAs-microRNAs Network Dysregulation and Cellular Hallmarks of Thyroid Cancer.Cancers · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies have progressively clarified the critical role of long non-coding RNA (lncRNA) in cancer, especially concerning its involvement in immune processes, which holds significant therapeutic promise. However, the incorporation of lncRNA into immunotherapy has yet to demonstrate adequate clinical efficacy. This shortcoming can be attributed to various challenges, including unclear mechanisms of action and limited prognostic capacity. In colorectal cancer (CRC), this ineffectiveness may predominantly stem from immune escape mechanisms mediated by lncRNAs. Despite some exploration into lncRNA-driven immune escape, a comprehensive overview of its implications for immunotherapy in CRC remains inadequately addressed. In this review, we thoroughly assess the role of lncRNA in immune escape mechanisms associated with CRC, focusing on immune checkpoints, immune cells, and cytokines. We elucidate the relationship between lncRNA-mediated immune escape and CRC progression and discuss strategies for lncRNA-mediated immunotherapy for CRC. Our aim is to provide fresh insights into the potential of targeting lncRNAs to enhance the effectiveness of immunotherapeutic strategies in CRC.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.