Evidence map›Paper›PMID 40537773›Full record

ArticleJournal of orthopaedic surgery and research2025

Hydroxylated fullerene promotes fracture healing in ovariectomized combined type 2 diabetic mice.

Yunpeng Hu, Linjie Feng, Jie Li, Fuyuan Cao, Xiaoli Hou, Wei Chen, Yimeng Zhang, Lei Xing, Jingyuan Gao, Liu Zhang and 2 more

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In one paragraph

Article in Journal of orthopaedic surgery and research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yunpeng Hu *School of Public Health, North China University of Science and Technology, Tangshan, Hebei, 063000, PR China.
Linjie Feng *Department of Orthopedic Surgery, The 982th Hospital of Joint Logistic Force of Chinese People's Liberation Army, Tangshan, Hebei, 063000, China.
Jie LiBeijing National Research Center for Molecular Sciences, Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100080, China.
Fuyuan CaoSchool of Public Health, North China University of Science and Technology, Tangshan, Hebei, 063000, PR China.
Xiaoli HouSchool of Public Health, North China University of Science and Technology, Tangshan, Hebei, 063000, PR China.
Wei ChenDepartment of Orthopedic Surgery, Hebei Medical University, Shijiazhuang, Hebei, 050023, China.
Yimeng ZhangMedical Department, The First Hospital of Hebei Medical University, Shijiazhuang, 050023, China.
Lei XingSchool of Public Health, North China University of Science and Technology, Tangshan, Hebei, 063000, PR China.
Jingyuan GaoDepartment of Rheumatology and Immunology, Affiliated Hospital of North China, University of Science and Technology, Tangshan, Hebei, 063000, China.
Liu ZhangSchool of Public Health, North China University of Science and Technology, Tangshan, Hebei, 063000, PR China.
Ye LiuDepartment of Anaesthesiology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, 100069, China. liuye@mail.ccmu.edu.cn.
Faming TianSchool of Public Health, North China University of Science and Technology, Tangshan, Hebei, 063000, PR China. tfm9911316@163.com.

Funding

Basic Scientific Research Funds Program of Universities in Hebei Province JYG2021005Central government-guided local science and technology Development foundation of Hebei Province 226Z7709GCentral government-guided local science and technology Development foundation of Hebei Province 246Z7744GNation Nature Science Foundation of China 31671235Nation Nature Science Foundation of China NSFC81874029One-Hundred Innovative Talents Support Foundation of Hebei Province JJK-2019-14the Natural Science Foundation of Hebei Province H2020209266Youth Talent Support Program of Hebei Province JI-2016-10
6 · The paper itself

Abstract

backgroundThe aim of this investigation was to assess the interventional role of hydroxylated fullerene in this model by histological, imaging, and biomechanical means in order to inform the treatment of fracture healing in a population of menopausal women with type 2 diabetes mellitus (T2DM).

methodsSixty-four female 8-week-old C57BL/6 mice were randomly divided into four groups: fracture (F), OVX + fracture (OF), T2DM + OVX + fracture (DOF), and hydroxylated fullerene-treated DOF (DOFF). A closed fracture was established in the right tibia of each mouse, which was performed 8 weeks after undergoing ovariectomy (OVX) in the OF, DOF, and DOFF groups. Hydroxylated fullerene (5 mg/kg, every two days) was administered intraperitoneally to the DOFF group starting the day after fracture. The right tibias were collected at 7 and 28 days post-fracture.

resultsThe systemic administration of hydroxylated fullerene significantly increased the microstructural parameters of the callus (including bone volume fraction [BV/TV] and connectivity density [Conn.D]), promoted BMP-2 expression and inhibited TNF-α expression in the callus at 7 days post-fracture, and increased the expression of type I collagen (COL1) and osteocalcin (OCN) in the callus at 28 days post-fracture.

conclusionHydroxylated fullerene may improve fracture healing in this diabetic mouse model by reducing the inflammatory response and promoting osteogenesis. These results suggest that hydroxylated fullerene may act as a therapeutic agent for fracture healing.

Indexed as

Diabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2Fracture HealingFullerenesOvariectomyTibial FracturesAnimalsFemaleHydroxylationMiceMice, Inbred C57BLFullerenes

Identifiers

PMID40537773
PMCPMC12178074

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.