ArticleJournal of translational medicine2025
Acute effects of a single bout of high-intensity strength and endurance exercise on cognitive biomarkers in young adults and elderly men: a within-subjects crossover study.
Article in Journal of translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Physical exercise and circulating α-Klotho in humans: a systematic review and meta-analysis with emphasis on older adults.Frontiers in sports and active living · 2026Pooled it
- High-intensity interval training differentially modulates acute BDNF and cognitive responses in young adult males: a randomized crossover trial.Scientific reports · 2026Trial
- Role of Exercise in Modulating the Brain-Heart Axis in Cardiovascular Diseases.International journal of molecular sciences · 2026Review
- Acute Skeletal Muscle Activation Through Physical Exercise and Its Effects on Cognitive Performance and Neurobiological Markers in Adults: A Scoping Review.Muscles (Basel, Switzerland) · 2026Review
- Integrative physiology of skeletal muscle for maintaining cognitive health.The Journal of physiology · 2026Review
- Klotho levels and biological age acceleration: Insights from a diverse cohort of middle-aged and elderly individuals.PloS one · 2026Article
- Integrated Multi-Tissue Transcriptomics Reveals Antagonistic Pleiotropy in Aging and Alzheimer's Disease.Computational and structural biotechnology journal · 2026Article
- A comment on "Acute effects of a single bout of high-intensity strength and endurance exercise on cognitive biomarkers in young adults and elderly men: a within-subjects crossover study".Journal of translational medicine · 2025Article
- Acute Neurochemical, Psychophysiological, and Cognitive Responses to Small-Sided Games vs. Running-Based HIIT in Young, Male Soccer Players.Healthcare (Basel, Switzerland) · 2025Article
- Serum parameters and energy balance during the Yukon Arctic Ultra: a multistage ultramarathon in Arctic conditions.Frontiers in nutrition · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundAlthough evidence for exercise-induced changes in neurocognitive biomarkers is emerging, research examining acute responses to different exercise regimes across sex and age is lacking. This study investigated serum concentrations of three neurocognitive biomarkers (i.e., Klotho, brain-derived neurotrophic factor (BDNF), and glycosylphosphatidylinositol-specific phospholipase D1 (GPLD1)) after acute strength and aerobic exercise, along with skeletal muscle gene expression.
methodsIn a within-subjects crossover design, blood samples of 19 young women, 20 young men, and 14 elderly men were taken before, immediately, 3 h and 24 h after one bout of strength training (ST) and high-intensity interval training (HIIT). Muscle biopsies were taken from a subgroup (n = 22) before, 3 h and 24 h after ST and HIIT for gene expression analyses. Time changes and baseline levels, including the influence of sex and age, were analyzed using a multilevel model and Welch's analysis of variance, respectively. Biomarker levels were adjusted for exercise-induced plasma volume changes.
resultsSerum concentration of all biomarkers increased after ST and HIIT but were not affected by sex or age. While serum Klotho and BDNF levels peaked immediately after exercise in all groups, serum GPLD1 levels were highest at 3 h (young groups only). Age was a determining factor for baseline measures; young men had higher and lower resting serum Klotho and BDNF concentration, respectively, than elderly men. Muscle gene expression of Klotho increased after both exercise modes, and BDNF and GPLD1 expression was reduced within 24 h.
conclusionsCirculating levels of biomarkers linked to brain health can acutely be increased by one bout of ST or HIIT. This increase might be related to altered gene expression of these proteins in skeletal muscle. Ultimately, this could have beneficial implications for the management of mental and neurocognitive impairments.
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Registered trials
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