ArticleImmunity & ageing : I & A2025
Associations of serum total light chain kappa and lambda levels with all-cause mortality in Chinese centenarians.
Article in Immunity & ageing : I & A, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Association between the uric acid-to-albumin ratio and risk of all-cause mortality in centenarians: a prospective cohort study.Frontiers in nutrition · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors.
Funding
Abstract
The purpose of this study was to determine the relationship between the serum levels of kappa (κ) and lambda (λ) total light chain (TLC), the κ/λ ratio, and the combined serum TLCκ and TLCλ (ΣTLC) levels in Chinese centenarians and all-cause mortality. The association between serum TLC and all-cause mortality was investigated using restricted cubic spline (RCS) analysis, Cox proportional hazards models, and Kaplan‒Meier curves. The study included 906 centenarians (18.8% male), 838 (92.5%) of whom died during a median follow-up of 30 months. The proportions of centenarians with abnormal TLCκ and TLCλ levels were 68.1% and 49.0%, respectively. RCS analysis indicated that the levels of TLCκ, TLCλ, and ΣTLC were associated with all-cause mortality (P < 0.05), whereas the κ/λ ratio was not (P > 0.05). Cox proportional hazards analysis demonstrated that the highest quartiles of TLCκ, TLCλ, and ΣTLC were associated with an increased risk of death, with hazard ratios of 1.434 (95% confidence interval [CI], 1.061-1.939; P = 0.019), 1.351 (95% CI, 1.013-1.802; P = 0.041), and 1.891 (95% CI, 1.347-2.654; P < 0.001), respectively. Kaplan-Meier analysis illustrated that centenarians with higher levels of TLCκ, TLCλ, and ΣTLC had significantly shorter median survival times (26 months versus 35 months, P < 0.001; 26 months versus 32 months, P = 0.003; and 26 months versus 36 months, P < 0.001, respectively). Our findings suggest that serum levels of TLCκ, TLCλ, and ΣTLC are significantly associated with all-cause mortality in centenarians. Trial registration Not applicable.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.