Evidence map›Paper›PMID 40537805›Full record

ArticleJournal of nanobiotechnology2025

Intelligent ROS therapy driven by iron-based nanozyme with controllable catalytic activity for infected wound healing.

Lixue Deng, Yanni Cheng, Jia Liu, Ye Yuan, Cheng Zhou, Chundong Yao, Jia Sun, Zhixin Zhou, Zuoyu Chen, Zheng Wang and 1 more

Abstract read
In one paragraph

Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lixue Deng *Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Yanni Cheng *Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Jia LiuResearch Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. jialiu1207@hust.edu.cn.
Ye YuanDepartment of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Cheng ZhouDepartment of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Chundong YaoResearch Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Jia SunResearch Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Zhixin ZhouResearch Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Zuoyu ChenDepartment of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Zheng WangResearch Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. zhengwang@hust.edu.cn.
Lin WangResearch Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. lin_wang@hust.edu.cn.

Funding

Hubei Province Natural Science Foundation 2024AFA053Hubei Province Science and Technology Innovation Team Project [2022] No.11Knowledge Innovation Special Project for Fundamental Research of Wuhan 2022020801010461Major Scientific and Technological Innovation Projects in Hubei Province 2022BCA013National Key Research and Development Program of China 2022YFC2408100National Natural Science Foundation of China 82072068National Natural Science Foundation of China 82072167National Natural Science Foundation of China 82173315Union Hospital Foundation for Young Scientist 2021xhqh01
6 · The paper itself

Abstract

Therapeutic generation of reactive oxygen species (ROS) through catalytic therapy demonstrates antibacterial efficacy against wound infections. However, prolonged and unregulated ROS production risks inducing intolerable oxidative stress alongside exacerbated inflammatory responses, creating a microenvironment counterproductive to wound healing. Here, inspired by rechargeable batteries, we have developed a catalytic activity-controllable nanozyme by integrating Fe

Indexed as

Anti-Bacterial AgentsIronMetal-Organic FrameworksReactive Oxygen SpeciesWound HealingWound InfectionAnimalsCatalysisHumansHydrogen PeroxideHydroxyl RadicalMethicillin-Resistant Staphylococcus aureusMiceMicrobial Sensitivity TestsStaphylococcal InfectionsStaphylococcus aureusAnti-Bacterial AgentsHydrogen PeroxideHydroxyl RadicalIronMetal-Organic FrameworksReactive Oxygen SpeciesAdjustable enzyme activityBacterial infectionChemodynamic therapyNanozymeWound repair

Identifiers

PMID40537805
PMCPMC12178039

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.