Evidence map›Paper›PMID 40537813›Full record

ArticleImmunity & ageing : I & A2025

Frequency of synaptic antigen-specific CD4

Julius Hoffmann, Marie-Luise Machule, Jakob Kreye, Laura Stöffler, Péter Körtvelyessy, Maria Buthut, Rosa Rößling, Petra Bacher, Alexander Scheffold, Harald Prüss

Abstract read
In one paragraph

Article in Immunity & ageing : I & A, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Julius HoffmannGerman Center for Neurodegenerative Diseases (DZNE) Berlin, c/o Charité - Universitätsmedizin Berlin, Charitéplatz 1, Berlin, 10117, Germany. julius.hoffmann@charite.de.
Marie-Luise MachuleGerman Center for Neurodegenerative Diseases (DZNE) Berlin, c/o Charité - Universitätsmedizin Berlin, Charitéplatz 1, Berlin, 10117, Germany.
Jakob KreyeGerman Center for Neurodegenerative Diseases (DZNE) Berlin, c/o Charité - Universitätsmedizin Berlin, Charitéplatz 1, Berlin, 10117, Germany.
Laura StöfflerGerman Center for Neurodegenerative Diseases (DZNE) Berlin, c/o Charité - Universitätsmedizin Berlin, Charitéplatz 1, Berlin, 10117, Germany.
Péter KörtvelyessyDepartment of Neurology and Experimental Neurology, Freie Universität Berlin, Humboldt-Universität Zu Berlin, Berlin Institute of Health, Charitéplatz 1, Berlin, 10117, Germany.
Maria ButhutGerman Center for Neurodegenerative Diseases (DZNE) Berlin, c/o Charité - Universitätsmedizin Berlin, Charitéplatz 1, Berlin, 10117, Germany.
Rosa RößlingGerman Center for Neurodegenerative Diseases (DZNE) Berlin, c/o Charité - Universitätsmedizin Berlin, Charitéplatz 1, Berlin, 10117, Germany.
Petra BacherInstitute of Immunology, Christian-Albrecht-University of Kiel, Kiel, Germany.
Alexander ScheffoldInstitute of Immunology, Christian-Albrecht-University of Kiel, Kiel, Germany.
Harald PrüssGerman Center for Neurodegenerative Diseases (DZNE) Berlin, c/o Charité - Universitätsmedizin Berlin, Charitéplatz 1, Berlin, 10117, Germany.

Funding

Bundesministerium für Bildung und Forschung Connect-Generate 16GW0279KDeutsche Forschungsgemeinschaft FOR3004, PR1274/9-1, clinical research unit 5023/1 'BECAUSE-Y' [project number 504745852]Helmholtz-Fonds HIL-A03 BaoBab
6 · The paper itself

Abstract

Neurodegenerative dementias including Alzheimer disease severely impair cognitive and social abilities and are a major cause of mortality with no causal treatment yet. Autoimmune mechanisms have been increasingly considered to contribute to disease progression, e.g. by enhancing protein misfolding or pro-inflammatory immune responses. Understanding this contribution may lead to novel treatment options beyond removing neurodegeneration-associated proteins. We hypothesized that CD4

Indexed as

DementiaImmune senescenceLGI1MGluR5NMDA receptorSynaptic autoantigensT cells

Identifiers

PMID40537813
PMCPMC12178052

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.