ArticlePhysiological reports2025
Age and sex differences in blood pressure regulation: A focus on the vascular baroreflex limb.
Article in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Age and sex differences in blood pressure regulation: A focus on the vascular baroreflex limb.Physiological reports · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Despite the vasculature's role in long-term blood pressure (BP) regulation, limited work exists on vascular baroreflex function. This study focused on hypothesized age and sex differences in the vascular-sympathetic baroreflex limb and explored the role of hormone replacement therapy (HRT). Resting cardiac and hemodynamic measures were recorded. Baroreflex sensitivity (BRS) and baroreflex effectiveness (BEI) were calculated for each baroreflex limb (cardiac, myocardial, and vascular). In younger adults, women had significantly lower SBP, total peripheral resistance (TPR), and vascular-BEI than men (r's > 0.245, p's < 0.012). In older adults with managed-hypertension, post-menopausal women had significantly higher SBP, TPR, and vBEI, than men (r's > 0.228, p's < 0.018), while younger women had significantly higher vBRS (r's > 0.199, p's < 0.027) and lower TPR (r's > 0.281, p's < 0.002). Younger men showed significantly higher vascular-BRS and vascular-BEI (r's > 0.318, p's < 0.002), higher TPR and TPR-variability (r's > 0.314, p ≤ 0.003), and lower SBP (r's > 0.295, p's < 0.005) than older men. Compared to non-HRT women, HRT-women had only significantly lower SBP (r = 0.243, p = 0.035). We provide the first evidence of age and sex differences in vascular baroreflex-mediated BP control using the sequence method.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.