Evidence map›Paper›PMID 40538265›Full record

ArticleAnnals of medicine2025

Association of hs-CRP/HDL, AIP and NHHR with chronic obstructive pulmonary disease: a cross-sectional NHANES study.

Jiangyue Qin, Bi Ran, Yanqiu Wu, Dan Xu, Lian Liu, Diandian Li, Lei Chen, Fuqiang Wen

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Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jiangyue QinDepartment of Respiratory and Critical Care Medicine, West China Hospital and Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, Sichuan University, Chengdu, Sichuan, China.
Bi RanDepartment of Respiratory and Critical Care Medicine, West China Hospital and Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, Sichuan University, Chengdu, Sichuan, China.
Yanqiu WuDepartment of Respiratory and Critical Care Medicine, West China Hospital and Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, Sichuan University, Chengdu, Sichuan, China.
Dan XuDepartment of Respiratory and Critical Care Medicine, West China Hospital and Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, Sichuan University, Chengdu, Sichuan, China.
Lian LiuDepartment of Respiratory and Critical Care Medicine, West China Hospital and Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, Sichuan University, Chengdu, Sichuan, China.
Diandian LiDepartment of Respiratory and Critical Care Medicine, West China Hospital and Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, Sichuan University, Chengdu, Sichuan, China.
Lei ChenDepartment of Respiratory and Critical Care Medicine, West China Hospital and Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, Sichuan University, Chengdu, Sichuan, China.
Fuqiang WenDepartment of Respiratory and Critical Care Medicine, West China Hospital and Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, Sichuan University, Chengdu, Sichuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInflammation and dyslipidemia have been proven to be associated with chronic obstructive pulmonary disease (COPD). The purpose of this study was to evaluate the relationships between hS-CRP/HDL, AIP, NHHR and COPD. MATERIALS AND

methodsThe data was obtained from the National Health and Nutrition Examination Survey. Participants were classified into two groups based on self-reported COPD diagnosis. The hS-CRP/HDL, AIP and NHHR were evaluated for their potential correlation with COPD using the univariate and multivariable logistic regression models. Subsequently, restricted cubic spline (RCS) model was used to further explore the associations between hS-CRP/HDL, AIP, NHHR and COPD. Finally, subgroup analysis and interaction tests were applied.

results10419 participants were included, and 1168 of them were self-reported COPD. lg(hs-CRP/HDL) and AIP were statistically significantly elevated in the COPD group compared to those in non-COPD group, while NHHR was not significantly different between the two groups. In a multivariate logistic regression model that adjusted for all relevant factors, there was a 64% increase in the prevalence of COPD for every unit rise in hs-CRP/HDL (OR 1.64 [CI 1.31-2.05]). A significant positive association between hs-CRP/HDL and COPD was observed in most subgroups. However, the AIP and NHHR were not associated with COPD after adjusted for all relevant factors. RCS model supported a positive linear association of hs-CRP/HDL with COPD , and no linear or non-linear association of AIP, or NHHR and COPD.

conclusionsThe study suggests elevated hs-CRP/HDL may related to COPD, suggesting its potential as diagnostic marker for COPD.

Indexed as

C-Reactive ProteinPulmonary Disease, Chronic ObstructiveAdultAgedBiomarkersCross-Sectional StudiesDyslipidemiasFemaleHumansInflammationLogistic ModelsMaleMiddle AgedNutrition SurveysPrevalenceRisk FactorsBiomarkersC-Reactive ProteinAIPCOPDcross-sectional studyhsCRP/HDLNHANESNHHR

Identifiers

PMID40538265
PMCPMC12931298

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.