Evidence map›Paper›PMID 40538392›Full record

ArticleSleep and biological rhythms2025

Correlation study of 5-HT in brain with cognitive function and anxious-like behavior in APP/PS1 transgene mice.

Li Yuan, Linshan An, Rui Xie, Jiahong Cai, Dong Li, Xiaorong Chen, Wenjing Guo, Yinran Lin, Chunjing Zhu, Yongli Chang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sleep and biological rhythms, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Li YuanDepartment of Physiology, Changzhi Key Laboratory of Brain Diseases and Cognitive Behavior Research, Changzhi Medical College, No. 161, Jiefang East Street, Changzhi, Shanxi People's Republic of China.
Linshan AnDepartment of Physiology, Changzhi Key Laboratory of Brain Diseases and Cognitive Behavior Research, Changzhi Medical College, No. 161, Jiefang East Street, Changzhi, Shanxi People's Republic of China.
Rui XieDepartment of Ophthamology, Changzhi Medical College Affiliated Heping Hospital, No. 110, Yan'an South Road, Changzhi, Shanxi People's Republic of China.
Jiahong CaiDepartment of Physiology, Changzhi Key Laboratory of Brain Diseases and Cognitive Behavior Research, Changzhi Medical College, No. 161, Jiefang East Street, Changzhi, Shanxi People's Republic of China.
Dong LiDepartment of Stomatology, Changzhi Medical College Affiliated Heping Hospital, No. 110, Yan'an South Road, Changzhi, Shanxi People's Republic of China.
Xiaorong ChenDepartment of Physiology, Changzhi Key Laboratory of Brain Diseases and Cognitive Behavior Research, Changzhi Medical College, No. 161, Jiefang East Street, Changzhi, Shanxi People's Republic of China.
Wenjing GuoDepartment of Physiology, Changzhi Key Laboratory of Brain Diseases and Cognitive Behavior Research, Changzhi Medical College, No. 161, Jiefang East Street, Changzhi, Shanxi People's Republic of China.
Yinran LinDepartment of Physiology, Changzhi Key Laboratory of Brain Diseases and Cognitive Behavior Research, Changzhi Medical College, No. 161, Jiefang East Street, Changzhi, Shanxi People's Republic of China.
Chunjing ZhuDepartment of Physiology, Changzhi Key Laboratory of Brain Diseases and Cognitive Behavior Research, Changzhi Medical College, No. 161, Jiefang East Street, Changzhi, Shanxi People's Republic of China.
Yongli ChangDepartment of Physiology, Changzhi Key Laboratory of Brain Diseases and Cognitive Behavior Research, Changzhi Medical College, No. 161, Jiefang East Street, Changzhi, Shanxi People's Republic of China.
Kunbo WangDepartment of CLASS, Xiangya School of Medicine, Central South University, No. 172, Tongzipo Road, 2202 Yuelu District, Changsha City, People's Republic of China.
Weina HanDepartment of Physiology, Puai School of Medicine (Health Science Center), Shaoyang University, Shaoyang, Hunan Province People's Republic of China.
Lingna HanDepartment of Physiology, Changzhi Key Laboratory of Brain Diseases and Cognitive Behavior Research, Changzhi Medical College, No. 161, Jiefang East Street, Changzhi, Shanxi People's Republic of China.ORCID 0000-0002-8759-8767

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive decline in cognitive function and emotional disturbances. The amygdala is an important connectivity structure in the brain and is responsible for emotional responses. 5-HT is involved in various neurodevelopmental processes in the brain. In this study, correlation study of 5-HT in brain with cognitive function and anxious-like behavior was investigated in APP/PS1 transgene mice. Multiple behavioral tests were performed to examine the cognitive function and anxiety behavior of AD mice. In vivo hippocampus long-term potentiation (LTP) was recorded to reflect synaptic plasticity. 5-HT levels in hippocampus and amygdala were determined. Further, we explored the correlation between 5-HT levels in hippocampus and amygdala and long-term cognitive behaviors and anxiety behaviors in the AD mice using linear regression analysis. Our results demonstrated that there was close linear correlation between 5-HT level in brain and spatial cognition and anxiety behavior of APP/PS1 transgene mice. 5-HT influences spatial learning and memory by regulating the synaptic plasticity in hippocampus of APP/PS1 transgenic mice. These results indicate that 5-HT might be potentially beneficial in the treatment of AD.

Indexed as

5-HT transmitterAlzheimer’s diseaseCognitive function and emotionLinear regression analysisSynaptic plasticity

Identifiers

PMID40538392
PMCPMC12173973

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.