SynthesisFrontiers in aging neuroscience2025
Functional brain changes in vascular cognitive impairment: a whole brain ALE meta-analysis.
Synthesis in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- The enigma of vascular dementia: current state and emerging perspectives.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Compound Congrong Yizhi capsule partially remodels the fronto-retrosplenial-hippocampal memory circuit in vascular dementia rats.Frontiers in neurology · 2026Article
- Molecular pathways in vascular cognitive impairment and dementia: focus on synaptic plasticity and epigenetic modifications.Frontiers in aging neuroscience · 2026Review
- Amygdala functional connectivity and response to aerobic exercise in subthreshold depression-an exploratory fMRI study.BMC psychiatry · 2025Article
- Reorganization of the sensorimotor cortex in patients with Ph-negative myeloproliferative neoplasms according to functional MRI.Frontiers in neuroscience · 2025Article
- Targeting the blood-brain barrier with phytochemicals to attenuate vascular cognitive impairment: mechanisms and therapeutic potential across etiologies.Frontiers in nutrition · 2025Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Vascular cognitive impairment (VCI) is a prevalent form of cognitive dysfunction. Resting-state functional magnetic resonance imaging (rs-fMRI) could serve as a potential biomarker for early detection. This study employed activation likelihood estimation (ALE) meta-analysis to investigate specific neural abnormalities in VCI patients. Methods: We systematically searched PubMed, Embase, and Web of Science for rs-fMRI studies on VCI that reported amplitude of low-frequency fluctuation (ALFF), regional homogeneity (ReHo), or functional connectivity (FC). Sixteen eligible fMRI studies were included in the ALE meta-analysis. Results: Compared to healthy controls (HCs), VCI patients exhibited the following rs-fMRI alterations. For ALFF, there was an increase in the left anterior cingulate (AC) and left inferior frontal gyrus, possibly a compensatory over - activation. Decreases were seen in regions like the bilateral precuneus and medial frontal gyri (mFG), linked to cognitive deficits. ReHo increased in the left claustrum and insula, suggesting enhanced local synchronization, but decreased in the right sub - gyral region and middle temporal gyru (MTG), which may relate to language issues. FC was enhanced in areas related to complex cognitive processes, yet reduced in regions crucial for memory. Conclusion: VCI patients exhibited distinct functional abnormalities in specific brain regions, reflecting their diverse cognitive impairments. These region-specific alterations may serve as potential biomarkers for early diagnosis and targeted intervention in VCI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.