ArticleRSC advances2025
LC-MS Orbitrap-based metabolomics using a novel hybrid zwitterionic hydrophilic interaction liquid chromatography and rigorous metabolite identification reveals doxorubicin-induced metabolic perturbations in breast cancer cells.
Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Zwitterionic stationary phases: advances and trends in the HILIC chromatography of biomolecules and pharmaceuticals.Analytical and bioanalytical chemistry · 2026Review
- Low-Temperature HILIC Provides Enhanced Separations and Stability for LC-MS-Based Metabolomics.Journal of proteome research · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The identification of metabolites in biological samples presents a challenge in untargeted metabolomics, mainly due to limited databases and inadequate chromatography. Current LC columns suffer from high pH instability (silica-based), low efficiencies and pressure limitations (polymer-based), or inadequate retention of polar/semi-polar metabolites (reverse-phase). In this study, a comprehensive LC-MS workflow was developed to address these limitations using a novel zwitterionic HILIC (Z-HILIC), high-resolution MS, deep-scan data-dependent acquisition (DDA), and a large chemical library comprising 990 standards. The method performance was evaluated and compared with a widely-used ZIC-
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.