Evidence map›Paper›PMID 40538774›Full record

ArticleFrontiers in behavioral neuroscience2025

Constitutive activity of the inhibitory G protein pathway mediated by non-visual opsin Opn7b reduces cFos activity in stress and fear circuits and modulates avoidance behavior.

Hanna Böke, Hannah Schulte, Maria Worm, Julia Bihorac, Brix Mücher, Martin Hadamitzky, Ida Siveke, Stefan Herlitze, Katharina Spoida

Abstract read
In one paragraph

Article in Frontiers in behavioral neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hanna BökeDepartment of General Zoology and Neurobiology, Ruhr-University Bochum, Bochum, Germany.
Hannah SchulteDepartment of General Zoology and Neurobiology, Ruhr-University Bochum, Bochum, Germany.
Maria WormDepartment of General Zoology and Neurobiology, Ruhr-University Bochum, Bochum, Germany.
Julia BihoracInstitute of Medical Psychology and Behavioral Immunobiology, Center for Translational Neuro- Behavioral Sciences (C-TNBS), University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Brix MücherDepartment of General Zoology and Neurobiology, Ruhr-University Bochum, Bochum, Germany.
Martin HadamitzkyInstitute of Medical Psychology and Behavioral Immunobiology, Center for Translational Neuro- Behavioral Sciences (C-TNBS), University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Ida SivekeDepartment of General Zoology and Neurobiology, Ruhr-University Bochum, Bochum, Germany.
Stefan HerlitzeDepartment of General Zoology and Neurobiology, Ruhr-University Bochum, Bochum, Germany.
Katharina SpoidaDepartment of General Zoology and Neurobiology, Ruhr-University Bochum, Bochum, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Constitutive activity of G protein-coupled receptors (GPCRs) plays an important role in brain function and disease including neurodegenerative and psychiatric disorders. The non-visual opsin Opn7b is a constitutively active G

Indexed as

aversive behaviorBNST (bed nucleus of the stria terminalis)cFosconstitutive activity of GPCRsGPCR (G protein coupled receptor)optogeneticsVTA (ventral tegmental area)

Identifiers

PMID40538774
PMCPMC12176751

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.