Evidence map›Paper›PMID 40538800›Full record

ArticleFrontiers in endocrinology2025

Association of IGF-1 and IGFBP-3 with metabolic abnormalities among children and adolescents.

Zhenghao Zhao, Yuanyuan Ma, Xinyi Zhang, Xiaoxiao Liu, Yang Li, Zhongze Fang, Rongxiu Zheng, Jing Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhenghao ZhaoDepartment of Toxicology and Health Inspection and Quarantine, School of Public Health, Tianjin Medical University, Tianjin, China.
Yuanyuan MaDepartment of Toxicology and Health Inspection and Quarantine, School of Public Health, Tianjin Medical University, Tianjin, China.
Xinyi ZhangDepartment of Toxicology and Health Inspection and Quarantine, School of Public Health, Tianjin Medical University, Tianjin, China.
Xiaoxiao LiuDepartment of Pediatrics, Tianjin Medical University, General Hospital, Tianjin, China.
Yang LiDepartment of Toxicology and Health Inspection and Quarantine, School of Public Health, Tianjin Medical University, Tianjin, China.
Zhongze FangDepartment of Toxicology and Health Inspection and Quarantine, School of Public Health, Tianjin Medical University, Tianjin, China.
Rongxiu ZhengDepartment of Pediatrics, Tianjin Medical University, General Hospital, Tianjin, China.
Jing LiTianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Objective: Insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) play roles in growth and development, but their association with metabolic abnormalities in children and adolescents remains unclear. This study aimed to investigate the relationship between IGF-1, IGFBP-3, and metabolic abnormalities in Chinese children and adolescents, while assessing the role of age in these associations. Methods: Participants were categorized into low-risk and high-risk groups based on metabolic abnormality criteria. Demographic, anthropometric, and laboratory data were collected via medical records. Logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Results: Data from 588 participants were analyzed. Higher IGF-1 (Q4: OR 0.24, 95% CI: 0.11-0.51) and IGFBP-3 levels (Q4: OR 0.38, 95% CI: 0.18-0.76) were associated with lower odds of metabolic abnormalities. Higher IGF-1/IGFBP-3 ratios also reduced metabolic abnormality risk. Age-related trends showed IGF-1 levels plateaued with age, while IGFBP-3 progressively increased, with the low-risk group consistently maintaining higher levels. Conclusions: Higher IGF-1 and IGFBP-3 levels are negatively associated with metabolic abnormalities in children and adolescents. Maintaining the balance of these factors is critical for metabolic health, especially during adolescence.

Indexed as

Insulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor IMetabolic DiseasesMetabolic SyndromeAdolescentBiomarkersChildChild, PreschoolChinaFemaleHumansMaleRisk FactorsBiomarkersIGF1 protein, humanIGFBP3 protein, humanInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor Iadolescentchildreninsulin-like growth factor-1insulin-like growth factor binding protein-3metabolic abnormalities

Identifiers

PMID40538800
PMCPMC12176600

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.